Vedolizumab is a recombinant humanized monoclonal antibody of isotype IgG1 raised against human lymphocyte ?4?7 integrin, a key mediator of gastrointestinal inflammation. It is used for the treatment of active ulcerative colitis and Crohn’s disease. Vedolizumab can reduce intestinal inflammation by blocking its main target ?4?7 integrin.
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