DNA immunization services and technologies have been developed and optimized at ProteoGenix in order to offer a successful alternative for custom polyclonal or monoclonal antibody generation against difficult-to-express targets but also for early DNA vaccine development studies. There are several other strong advantages of genetic immunization for antibody production over other antibody development methods.
15 years of expertise in monoclonal antibody development: Our experienced team of account managers can guide you to design the most appropriate strategy to develop the most suitable antibodies for you.
Our prices are among the most competitive ones on the market with unrivaled guarantees.
Injections are optimized to allow reaching high titers for any kind of protein.
DNA to Antibody
Everything can be included from gene synthesis to the development of a stable cell line expressing your recombinant antibody.
We can also perform only small steps of the service and consider Go / No Go stops.
ProteoGenix’ team of account managers is available to study each customer project in order to define the most suitable strategy to develop antibodies meeting customers’ specifications in terms of antibody performances, deliverables, budget and lead time. Our wide range of technologies and solutions allows us to design optimal strategies no matter the constraints we have to face.
For DNA immunization programs more specifically, we possess an unrivaled experience in all steps of the process including codon optimization, gene synthesis, plasmid preparation, animal injection, hybridoma development and antibody purification. This experience allows us to provide integrated antibody production services by genetic immunization delivering antibodies of strong affinity at very affordable prices in a short period of time.
What material are antibodies screened and selected on?
Is this methos suited for all types of antigen species?
In which cell type is the antigen transfected?
Who should prepare the plasmid to inject?
Are nuclear antigens and transmembrane antigens good targets?
The principle of genetic immunization for antibody production is to inject to animals a plasmid DNA coding for the targeted antigen instead of injecting the target itself. Our proprietary plasmid that also serves as an adjuvant will transfect animal cells and conduct to in situ expression of the antigen, that will therefore be presented to the immune system in a form usually much closer to the native form of that antigen. The animal then responds normally to the protein target it has expressed in vivo. DNA immunization is therefore an outstanding tool to develop polyclonal and monoclonal antibodies against certain types of targets or to study DNA vaccine candidates at early stage. After years of research ProteoGenix has established high performing SOPs to develop high affinity antibodies through genetic immunization services.
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