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Best experts on board
Your affinity maturation project will benefit from 28 years of expertise in therapeutic antibody development in leading pharmaceutical companies.
Our priority is to ensure a safe investment to our customers! Our affinity maturation service includes unique guarantees determined after a in-depth preliminary study!
You get the full rights to the affinity matured antibodies at the end of the project!
PhD account managers
To ensure efficient communication for your affinity maturation projects, you have highly skilled PhD account managers at your disposal.
Large libraries of relevant antibodies
Our phage display library design uses 3D modeling in order to limit irrelevant mutations and more specifically to keep the most appropriate mutations and avoid the generation of junk into the library.
One stop solution
Put your trust in a unique partner to help bring your therapeutic antibody project straight to the clinic!
ProteoGenix has developed a high-class affinity maturation service tailored to increase the affinity of your antibody against its target. Besides affinity, cross-reactivity can also be introduced to avoid the use of surrogate antibodies for preclinical development. Many other parameters can be measured and optimized such as:
To do so, site-directed mutagenesis or random mutagenesis is performed on the CDR regions.
As affinity maturation is fairly complex, our experts define the most relevant strategy after a preliminary study. This is the best way to guarantee our customers a safe investment and to include unique result guarantees to your project. This demonstrates our commitment to the success of your antibody affinity maturation.
Preliminary study by our affinity maturation expert
Design and construction of a mutated phage display library
Library screening and variants selection
Sequencing and recombinant expression of the best variants
Recombinant antibody production
Stable cell line generation
Affinity maturation is important in diagnostics and biotherapeutics as well as many other applications requiring strong antibody-antigen interactions.
When developing antibodies, many features can be required such as functionality (inhibiting activities for instance), specificity, use in particular applications and of course affinity. But it can be tricky to select an antibody with all these features from the start. It is therefore relevant to first focus on the functionality and application before working on improving the affinity using our high-class phage display platform.
For more information or to get a quote for our phage display services with the use of Affinity Maturation, don’t hesitate to contact us.
Got a question or need a quote? Message us and we'll get back to you 48 hours or less.
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