Are you struggling to find a team of antibody experts with the skills, expertise, and versatility needed to quickly build a high-affinity custom antibody with superior performance? , ProteoGenix can help you navigate this process with confidence by harnessing our custom antibody development scientists. With over 20 years of experience, 30+ antibodies in clinical and pre-clinical trials, and 3 therapeutic antibodies on the market, we know a few things about antibody production. Our consultative, project check point strategy not only mitigates risks but also accelerates your project’s timeline, saving precious time and significantly enhancing successful custom antibody outcomes. From antibody production and development to antibody engineering and characterization, no project is too big or too small for our expert team. Talk to one of our experts about your antibody project today.


About us – ProteoGenix, an antibody production company

Founded in 2003, ProteoGenix initially focused on developing diagnostic assays and biotherapeutics targeting discovered proteins. Recognizing the value of high-quality antibodies and proteins, ProteoGenix ventured into the biopharmaceutical domain, aiming to facilitate access to clinical settings, becoming a leading antibody production company.

ProteoGenix quickly gained recognition as a trusted Contract Research Organization (CRO) and a preferred partner in the biopharmaceutical industry. Its expertise in therapeutic antibodies and custom assays significantly enhanced the success rate of its customized therapeutics advancing to the investigational new drug application stage.

ProteoGenix is more than an antibody production company. It also serves as a service integrator, guiding customers from early discovery to the clinic by anticipating future biomolecule requirements and designing tailor-made development strategies to proactively meet those needs. Its extensive portfolio of innovative solutions spans the following six complementary service areas:

  • Antibody engineering (Humanization, Bi-specific, ADC, affinity maturation, antibody optimization)
  • Bioprocess development (IP-free stable cell line development, fermentation, and bioreactor production optimization)
  • Monoclonal and polyclonal antibody development (Hybridoma method and Phage Display)
  • Recombinant protein and antibody production services (E. coli, B. subtilis, Yeast, Insect cells, Mammalian cells)
  • Gene synthesis
  • Peptide synthesis

Our research and development labs constantly influence our processes with outstanding innovations like our proprietary XtenCHO™ cell line for industry-leading antibody expression in mammalian cells.

ProteoGenix also boasts an extensive catalog of over 7,000 products available in their user-friendly online shop. This comprehensive collection encompasses antibodies, proteins, ELISA kits, cell separation media, and nucleic acid purification kits, ensuring easy access to a wide range of research tools.


How much does an antibody development cost?

The price of a custom antibody can vary from a few hundred euros for polyclonal antibodies to hundreds of thousands of euros for a therapeutic monoclonal antibody.

This difference in cost is mainly due to the completely different complexity of the development process. The development of polyclonal antibodies generally involves producing an antigen, immunizing animals, collecting, testing and possibly purifying the serum.

In addition to the complex generation of monoclonal antibodies, the development of therapeutic antibodies may involve various steps that meet the needs of today’s biopharmaceutical companies, including: improving affinity (affinity maturation), reducing immunogenicity (humanization), changing the antibody format (bispecific antibodies, ADCs, etc.), improving production yields (antibody developability, cell line development, etc.)… All these steps require time and extremely high levels of expertise, resulting in high costs. However, choosing experts who are capable of mastering the entire process can be extremely cost-effective, as it increases the chances of success in reaching the clinic while anticipating the problems of large-scale development. By choosing ProteoGenix, you can put all this expertise at your disposal and put all the chances on your side that your project will reach the clinic!


How long does it take to develop a custom antibody?

In the same way as for the cost, the development of an antibody can be extremely variable depending on the application and the method chosen. It can range from around one month for polyclonal antibodies to more than a year for a fully custom therapeutic antibody project.

This difference in time is mainly explained by a difference in the complexity of the process. Developing a polyclonal antibody involves producing an antigen, immunizing animals and then collecting, testing and possibly purifying the serum. The whole process generally takes between 1 and 2 months.

The development of a therapeutic monoclonal antibody involves, in addition to the complex generation of a monoclonal antibody, various engineering steps aimed at refining the properties of the antibody. These steps may include affinity maturation, humanization, improving developability, changing the antibody’s format (bispecific, ADC, etc.), each of which can take from several weeks to several months. If you’re pressed for time, our experts can advise you on the most suitable solutions for your custom antibody development.


From your requirements to your custom antibody

When working with ProteoGenix to develop a custom antibody, you can expect a step-by-step process that ensures high-performance results and tailored solutions for your specific needs.

  • Project Discussion: At the start of the project, you will engage in detailed discussions with one of our antibody experts so we can understand your requirements, objectives, and project timeline. This collaborative approach allows for effective project design and ensures that our process is aligned with your goals.
  • Antigen Preparation: Next, we will prepare a high-quality antigen that we will use to immunize animals and antibody purification. This involves the synthesis or production of the antigen based on the specifications discussed in the project discussion phase. Attention is given to ensuring the antigen’s quality, purity, and suitability for generating the desired antibody response.
  • Animal Immunization: This step applies to polyclonal antibody development projects or monoclonal projects using single B cell isolation, hybridoma, or customs immune phage display library generation projects. Following antigen preparation, the selected animals will be immunized with the antigen. ProteoGenix will then employ established immunization protocols to stimulate the production of specific antibodies against the target antigen.
  • Antibody Development: Once the animals have generated an immune response, blood samples will be collected, and the antibody-containing serum or the B cell compartment will be processed.
  • Antibody Expression and Purification: In cases where recombinant antibody production is required, ProteoGenix will employ advanced expression systems to produce the antibodies in a controlled laboratory setting. This ensures consistent and scalable production of the desired antibodies. Following expression, purification methods will be utilized to obtain highly pure and functional antibodies.


Throughout the entire process, you can expect access to ProteoGenix’s experienced scientists, who will guide you from project design to delivery. Their expertise and attention to detail, along with rigorous quality assurance measures, will ensure the development of customized antibodies that meet your specifications and deliver reliable performance for your research or diagnostic applications.