Stable Istotope Labelled Mepolizumab Biosimilar – Anti-IL5 mAb – Research Grade

Reference: PX-TA1062-SIL-1MG
Product nameStable Istotope Labelled Mepolizumab Biosimilar - Anti-IL5 mAb - Research Grade
SourceCAS 196078-29-2
SpeciesHumanized
Expression systemMammalian cells
Purity>95%
BufferPBS buffer PH7.5
Delivery conditionBlue Ice
Delivery Time3-5 days if in stock; 5-8 weeks if production needed
Storage conditionstore at -80°C
BrandProteoGenix
Aliases /SynonymsSB-240563
ReferencePX-TA1062-SIL
Related ProductsPX-P4558
NoteFor research use only. Not suitable for clinical or therapeutic use.
IsotypeIgG1-kappa
ClonalityMonoclonal Antibody
SourceCAS 196078-29-2
FormatLyophilized
LabellingArginine: 13C6,15N4 ; Lysine: 13C6,15N2, >99%
Isotopic Enrichment99%
Stability1 year

General information on Anti-IL5(Homo sapiens) (Mepolizumab) Monoclonal Antibody

Mepolizumab is a fully humanized recombinant IgG1 kappa monoclonal antibody directed against IL-5 produced in Chinese hamster ovary cells. (EGPA) and eosinophilia syndrome (HES). The pathogenesis of eosinophils is complex, but IL-5 is considered a key eosinophilic factor, involved in the differentiation, recruitment, activation and prolonged survival of eosinophils in peripheral tissues. Activated eosinophils further stimulate the inflammatory response, and also induce tissue damage and promote fibrosis, all of which contribute to the multifactorial symptoms of eosinophilic disease. Mepolizumab is used to treat severe asthma and is sold under the trade name Nucala.

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