ProteoGenix has solved some issues offering a unique rabbit monoclonal antibody production service using phage display antibody library technique.
Rabbit monoclonal antibodies constitute a class of reagents with very high added value for research, diagnostic and therapeutic applications.
They have naturally:
Higher affinity (excellent for IHC usage)
Higher specificity (higher signal to noise ratio)
Excellent for post translational modification detection
as well as higher epitopes recognition compared to other monoclonal antibodies. READ MORE >
Rabbit monoclonal antibodies are mostly derived from hybridomas, which are generally not well characterized and show sometimes high batch-to-batch variability.
The hybridoma method screening is very limited (~103), oftentimes it misses rare clones and it takes a while to produce antibodies (approximately 9 months). Additionally, clones are very often unstable and antibody production from them can be troublesome. In contrast, phage display combines the superior antigen recognition of the rabbit immune system with the specificity and consistency of a monoclonal generated via hybridoma development without all the drawbacks of rabbit hybridomas. .