ProteoGenix offers VHH single domain antibody production. Our service includes:

 

The construction of an immune library using our alpacas/llamas or the use of our naive library

Bio-panning of naive or immune libraries via phage display technology

Large scale production of VHH single domain antibody

Library construction and phage display screening: 8 900 €

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What is a VHH single domain antibody?

 

Conventionally we use IgG antibodies from mice, rat, rabbit etc. They have a size of 150kDa and are composed of 2 heavy and 2 light chains.


Advantages using VHH single domain antibody

  • SMALL SIZE

    The smaller size of VHH single domain antibodies gives them the ability to fit into “hidden” epitopes that are usually not accessible to conventional antibodies, including active site of many enzymes

  • HIGHLY STABLE

    VHH single domain antibodies are highly stable and resistant to acid solution and high temperatures, they are able to fold back into a functional protein after denaturation

  • HIGHLY SOLUBLE

    VHH single domain antibodies are highly soluble due to their increased hydrophilic function

The main advantage of VHH single domain antibodies is that they have outstanding binding properties and can be expressed at constant high quality without batch-to-batch variation.
Due to their high affinity and binding specificities; these types of antibodies are robust tools for a lot of bioassays and applications.

VHH single domain antibody production steps

 


Featured VHH single domain antibody applications

 

There are a lot of applications described in scientific publications of VHH single domain antibodies due to their smaller size which leads to a better tissue penetration. You can find detailed information for:

  • therapeutic applications,
  • crystallography applications,
  • biotechnological applications,
  • diagnostics applications etc.

We believe that VHH single domain antibodies are a good choice for a lot of applications and assays.

For more information or to get a quote for our service, don’t hesitate to contact us.