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THERAPEUTIC ANTIBODY SERVICES

Home/Drug Discovery

As a leading contract research organization, ProteoGenix has an extensive experience in the development of optimized therapeutic monoclonal antibodies. Our unique portfolio of integrated services allows us to guide you through your antibody drug discovery challenge from target selection to clinical candidate.

Why choose ProteoGenix's therapeutic antibody services?

Guaranteed therapeutic antibody generation
Guarantees

each go/ no go steps are accompanied by guarantees based on the success of the step. You keep the control of the process while transferring risks to us.

Decreased time to market
Decreased time to market

one partner from target selection to the clinic thanks to a streamlined mAb development process.

FTO free therapeutic antibody
IP free

you get full ownership and exclusive rights of the antibodies developed.

Increased success rate
Increased success rate

to make it to the market: we strive to develop the best possible antibody as we understand that it plays a major role to reach the market.

Wide range of antibody development solutions
Wide range of solutions

we propose a complete toolbox to deliver you a clinical candidate with optimal properties to reach the clinic and the market.

Therapeutic antibody generation expertise
Strong support

our highly skilled experts guide you along the whole therapeutic drug development process and provide you the most relevant scientific data to make your decisions.

State of the art equipment for therapeutic antibody discovery
State of the art equipment

your project deserves the best equipment to be realized in an efficient manner.

Custom antibody drug development process
Custom process

our drug development process is fully customizable. You can start at each step of the process depending on your project progress.

A fully integrated therapeutic antibody development solution from your target to your clinical candidate

Outsourcing early therapeutic antibody discovery and development is often driven by the ability of your service provider to propose integrated solutions. Using a unique partner from target selection to the clinic presents several advantages:

  • Better control of the process

  • Decreased time to market

  • Easier project management

  • Significant increase in success rate

  • Less risk and unique levels of guarantees

  • Less administrative work

These considerations are of primary importance in the drug development race. ProteoGenix understands these major issues. For this reason, we put our 15 years of expertise at your disposal to support your antibody drug discovery and development process.

As each project is unique, our experts design a custom and optimized project plan to reach your target. However, we know that drug discovery and development is not a static and always predictable process. For this reason, ProteoGenix offers therapeutic antibody services including several milestones (Go / No Go) along the process and we help our customers in their decision-making by generating relevant scientific data. These steps also represent unique opportunities to discuss about the project progresses and the future outcomes in-depth.

Choosing ProteoGenix means working with a company which developed more than 300 monoclonal antibodies and more than 100 recombinant proteins for various applications. Our extensive experience in the development and engineering of antibodies allows us to propose a wide range of solutions to successfully develop your clinical candidate. That is also why we trust our capabilities to fulfill all your requirements and propose unrivalled guarantees at each step of our process.

Therapeutic antibody development with ProteoGenix: one project, several solutions

Therapeutic antibody development solutions

ANTIGEN DESIGN

A key factor of success in the generation of high-quality antibodies depends on the quality of the antigen design. With more than 300 monoclonal antibodies successfully developed, ProteoGenix is the best choice for your antigen design. We combine the largest panel of antigen design solution (DNA, peptide, 5 different protein expression systems, cell) with the highest expertise on the market to synthesize antigen corresponding to the closest form of your native target. Provide us your target sequence and our scientists will define the best strategy to generate high-quality antibodies.

 

Offer the best start to your project by working with ProteoGenix!

THERAPEUTIC ANTIBODY LEAD GENERATION

Bringing the most adapted answer to your project is our first priority. For this reason, ProteoGenix offers the choice between in vivo (hybridoma development or phage display on immune library) and in vitro (phage display on naive library) antibody generation techniques.

 

ProteoGenix proposes a wide range of services related to the phage display technique to generate the best binders for your therapeutic applications. Phage display is the perfect method to discover novel monoclonal antibodies. Our strong expertise in the construction and screening of phage display libraries allows us to propose:

 

  • The largest naive and immune libraries on the market (up to 1010 clones)

  • In 5 different species: human (Fab, scFv), rabbit (Fab, scFv), mouse (Fab, scFv), llama (VHH), alpaca (VHH)


Choosing our phage display services means also benefiting from
at least 3 different binders guaranteed that can be optimized using our best-in-class therapeutic engineering services.

Hybridoma development is another reference when it comes to develop therapeutic antibodies. Generating high-quality hybridomas requires choosing the best immunization strategy. For this reason, ProteoGenix offers the largest panel of solutions: peptide, protein, cell or DNA immunization. The hybridomas obtained are selected and guaranteed in the functional assay of your choice.

Whether your challenge implies a difficult-to-express target or even short timelines… Our highly-skilled scientists surely have the most accurate solution.

THERAPEUTIC ANTIBODY ENGINEERING

An ideal therapeutic antibody should demonstrate high affinity, high specificity and no immunogenicity. To pave the way to your future blockbuster, ProteoGenix offers a complete toolbox of high-class antibody engineering services including:

 

  • Humanization services

  • Affinity maturation services

  • Reformatting services : bispecific antibodies, antibody-drug conjugates, fusion protein antibodies

  • Subtype switching

  • Isotype switching

BIOANALYTICS

Characterizing your leads is of primary importance when it comes to the selection of your best candidate. Going to the wrong direction can imply significant money and time losses and, in the worst case, lead to the end of the project.

 

Making the right decision requires the right information. For this reason, ProteoGenix provides a full-set of biochemical, biophysical and functional characterization including:

  • Antibody integrity analysis : non-reducing and reducing SDS-PAGE

  • IgG quantification : UV280, Octet Red96, Bradford

  • Biological potency : ADCC & CDC

  • Binding analysis : ELISA, Octet Red96

  • Aggregate analysis : SEC-HPLC

  • Stability analysis : differential scanning calorimetry, IR

  • KD determination : SPR (Biacore), SPRi

  • Endotoxin detection test/ removal

  • Glycosylation profile analysis : IR, LC/MS

  • FACS analysis

  • Charge heterogeneity analysis : IEF-CE

  • Activity analysis against the antigen : ELISA, sandwich ELISA, WB

TRANSIENT OR STABLE CELL LINE PRODUCTION : XtenCHOTM

XtenCHO proprietary cell line

Not satisfied of your current antibody transient expression yield? Tried many other cell lines without success? It’s time to try XtenCHOTM.

Our unique proprietary cell line XtenCHOTM already overperformed many of the best cell lines on the market, including ExpiCHO, for the production of therapeutic antibodies such as Utomilumab and Pembrolizumab (yields up to 800 mg/L).

You earn a future blockbuster but you are not reaching high antibody stable expression yield? Offer to your project our “yield-guaranteed” stable cell line development service to reach antibody expression yields up to 3 g/L.

ProteoGenix, state-of-the-art equipment fleet to bring your project straight to the clinic

ProteoGenix is continuously investing in new equipment to offer to its customers an access to the best technologies. Here are few examples of the latest investments made to propose you cutting-edge science.

Third generation DNA sequencing equipment
Third generation sequencing solution
Automated HTP workstation equipment
High Throughput Beckmann Workstation
Bio-Rad equipment lab
Bio-Rad equipment lab

Let’s team up to move your therapeutic antibody development project to the clinic!

As a privileged partner for your therapeutic antibody generation, ProteoGenix is fully committed in contributing to the success of its customers' biotherapeutic projects. To reach this goal, we rely on the expertise of scientists having more than 25 years of experience in the development of therapeutic antibodies in different disease areas (including antibodies currently on the market and over 30 antibodies in clinical or preclinical phases) and on best-in-class equipment.

Let us support your therapeutic antibody discovery project and get access to the world most complete solution to develop your antibody drug candidate.