Stable Isotope Labeled Aflibercept Biosimilar – Anti-VEGF mAb – Research Grade

Reference: PX-TA1016-SIL-1MG
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Description of Aflibercept Biosimilar - Anti-VEGF mAb - Research Grade

General information about Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. This product is for research use only.

Product nameStable Isotope Labeled Aflibercept Biosimilar - Anti-VEGF mAb - Research Grade
SourceDrugBank DB08885
SpeciesHuman
Expression systemMammalian cells
Molecular weight115kDa
Purity>90%
BufferPBS pH7.5
Delivery conditionBlue Ice
Delivery Time3-5 days if in stock; 5-8 weeks if production needed
Storage condition4°C for short term; -20°C for long term
BrandProteoGenix
Aliases /SynonymsAflibercept
ReferencePX-TA1016-SIL
Related ProductsPX-P1167
NoteFor research use only. Not suitable for clinical or therapeutic use.
IsotypehG1-Fc
ClonalityMonoclonal Antibody
SourceDrugBank DB08885
FormatLyophilized
LabellingArginine: 13C6,15N4 ; Lysine: 13C6,15N2
Isotopic Enrichment99%
Stability1 year
FormulaC4318H6788N1164O1304S32

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