CD279 Recombinant Protein

Reference: PX-P4117-100



Product type

Host Species

Description of CD279 Recombinant Protein

General information on CD279 Recombinant Protein:

CD279 (programmed cell death protein 1; PD-1) is a type I transmembrane protein that belongs to the CD28 / CTLA-4 family of immune receptors, which mediates signals that regulate immune responses. Members of the CD28 / CTLA-4 family have been shown to promote T cell activation (CD28 and ICOS) or deactivate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, bone marrow cells, and some thymocytes. In vitro, CD279 binding can prevent TCR-mediated T cell proliferation and the production of IL-1, IL-4, IL-10, and IFN-?. Furthermore, the binding of CD279 can also prevent BCR signaling. CD279-deficient mice have defective peripheral tolerance and spontaneously develop autoimmune diseases.

Product nameCD279 Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight40kDa
Purity estimated>90% by SDS-PAGE
BufferC-terminal His Tag
Delivery conditionDry Ice
Storage conditionStore at - 20? to -80?. It is recommended that the protein be aliquoted for optimal storage.
Host speciesMammalian cells
Fragment TypeMet1~Val170
Aliases /SynonymsPD1
NoteFor research use only


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