+ Why choose ProteoGenix as your favorite solid phase peptide synthesis provider?

- Our success rate is higher than most other custom service suppliers.
- We have a strong experience in synthesizing difficult peptides: 100 to 150AA long peptides, hydrophobic peptides or repeated sequences…
- We provide the best prices together with guaranteed high quality standards.
- Our professional and pleasant sales team is devoted to serve our custom peptide synthesis clients carefully.
- We keep improving our fast delivery service.
- We offer a large range of possible conjugations and modifications.
- Purchasing peptide synthesis is very easy and fast at ProteoGenix!
- We provide high quality peptide synthesis for research.

Brief shortlist of all available peptide related services offered by ProteoGenix:
- fmoc solid phase Peptide synthesis
- Large range of Peptide modifications
- Peptide library synthesis and design
- Small to large scale peptide synthesis from mgs to kgs
- Simple, complex and circular peptide synthesis, with large repeats
- Very long sequences of more than 150 mer
- HPLC purities ranging from crude to above 99%
- Multiple Antigenic Peptides (MAPs)
- Use of special or unnatural amino acids like Homo-tyrosine, DL-m-tyrosine, Nal, Pal, 4-Cl-Phe-OH, D-amino acids, phosphotyrosine, beta amino acids…
- Arrays and libraries for screening or epitope mapping purposes
- Peptide content analysis (N%)

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As a world leader in custom peptide synthesis, ProteoGenix has offered high quality services at affordable prices for the last 13 years.


Peptide #1

1- Sequence

   

Nter modification Sequence of your peptide Cter modification
 This form can accept single-letter codes OR multiple-letter codes (you can not use both ways for the same peptide). However, please place braces {} around each multiple-letter entry: {Lys}{Phe}{d-Ala}.
 For any other Nter or Cter modifications, you can specify it below in the "Comments" fields.
 Under 5 amino acids, an account manager will send you a custom quotation.
 The minimum charge per peptide is 69€ before discount or any modification.

 Estimated unit price:
+ What purity would you advise me to use for my peptide synthesis project?
ProteoGenix proposes a large range of purity levels for your peptides:
- Crude peptide / Desalted peptide
- Immunograde peptide (purity >75%): the crude peptide is precipitated and washed several times for the complete extraction of organic impurities and to remove most secondary products. This level of purity of the peptides is usually enough for generating or testing antibodies.
- Purified peptides (purity >85%): further purification by preparative HPLC allows the elimination of peptides resulting from incomplete coupling (i.e. peptide lacking one or more amino acids). The 85% purified peptides can be used for antiserum production, ELISA antibody titration and monoclonal antibody production for example.
- Highly purified peptide (purity >95%): this level of purity is required for most biological or enzyme activity studies.
- Purity > 98% or > 99% can also be performed.
Name: Quantity: Purity:

If needed, please precise the quantity (between the given fork): mg

+ Proteogenix Guarantees…
All our peptides are guaranteed:
If we cannot provide you the amount, the purity and the sequence required, we do not charge anything, no matter the size of the peptide or the peptide modifications we have to do. We are devoted to provide high quality research peptide custom synthesis.
Quality is controlled by Mass spectrometry and HPLC and we always provide the corresponding profiles together with the peptide COA.
Solubilization advice can be provided if needed and you can download our free standard peptide solubilization guide following this link

The main reasons of our success in providing custom peptides are our highly trained team of chemists, our state of the art solid phase peptide synthesis platforms and our attractive pricing strategy due to massive economies of scale.

Fast delivery of your custom peptide synthesis and modification
Our optimized process for fast delivery allows us to ship your custom peptides within 2 to 3 weeks. We deliver anywhere in the world and apply minimum and reasonable shipping fees.

ProteoGenix’ fmoc solid phase peptide synthesis technology
ProteoGenix mainly uses fmoc solid phase peptide synthesis technology to produce the required amino acid sequences. It consists of assembling every fmoc protected amino acid via a specific resin. Once the molecule is assembled, it is first cleaved from the resin and then deprotected from the fmoc group also known as fluorenylmethoxycarbonyl group. The obtained crude product can then be purified by HPLC to get the desired purity from 70% to 99%. Other protection groups can also be used like t-Boc but fmoc leaves much less impurities in the final product and allows to get higher yields. It is therefore the best current method to reach our high quality production standards. This technology is widely used and has proven for the last 30 years to be the most reliable method available on the market.
We use many coupling reagents like BOP reagent, HBTU, HOBt, TBTU. Our most commonly used protecting reagents are Fmoc-Cl, Fmoc-OSu. We use linkers for solid phase method such as HMP linker, DHP linker, Rink amide linker.
In our manufactures, our scientists are using both manual and automated techniques but the flexibility of manual methods allows us to be able to deliver longer sequences.

2- Other peptide modifications

KLH (side chain of Cys) BSA (side chain of Cys) OVA (side chain of Cys)
Amide cyclic (Side chain, end) - Head to tail 5-TAMRA (side chain of Lys) Biotin (side chain of Lys)
Dansyl (side chain of Lys) 5-FAM (side chain of Lys) FITC (side chain of Lys)
Tyr (3-NO2) Abz / Tyr (3-NO2) EDANS or DABCYL
DABCYL/Glu(EDANS)-NH2 Multiple Antigenic Peptide System - Asymmetric 2 Branches (Pure) Multiple Antigenic Peptide System - Asymmetric 4 Branches (Crude)
Multiple Antigenic Peptide System - Asymmetric 8 Branches (Crude) N15/C13 Labeled peptides GMP like peptides
Other:
• Click here to see all the other modifications we can propose
3,5-dibromoTyrosine (D)1-Nal, (D)2-Pal, (D)4-Cl-Phe, Mpa, Dab, D-Beta-Asp, D-Abu, D-Gly(Allyl), D-Phg, Methacrylamid, Gamma-D, benzophenylalanine (Bpa) {beta-homoAla}
{beta-HomoAsp} {beta-HomoGlu} {beta-HomoTrp}
{beta-HomoVal} {Boc}, tertbutoxycarbonyl {Cpg}, cyclopentylglycine
{Cys(Me)}, SMC {D-2-Me-Trp} {Dec}, Decanoic acid C10
{D-HomoArg} {D-HPh}, D-HomoPhe {Har}, HomoArg
{HomoCit}, {D-HomoPro} {HomoLeu}, HomoLeu {HomoPro}
{L-1-Nal}/{D-1-Nal}, {L-2-Nal}/{D-2-Nal}, {L-2-Pal}/{D-2-Pal}, {L-3-Pal}/{D-3-Pal}, {L-4-Pal}/{D-4-Pal} {L-4-Cl-Phe}/{D-4-Cl-Phe}
{L-4-F-Phe}/{D-4-F-Phe} - 4-F-Phe {L-4-I-Phe}/{D-4-I-Phe} {L-4-NO2-Phe}/{D-4-NO2-Phe}
{Lys(Maleimide)}, (middle) {Ser(octanoic acid)} {Ste}, Stearic acidC18
12-Aminododecanoic acid 2-furoyl 3-(p-Hydroxyphenyl)propionic Acid
3-Indolylacetic acid (N-Terminal) 4-acetoamidobenzoic acid Anhydride bromoacetate (Br-CH2-CO)
Biotin (without Lys in sequence) Bip (Biphenylalanine) (N-Terminal) Br-Ac- {N terminus)}
Cinnamoyl : {Pal}, Palmitic acid C16 Cys(Acm), Cys(tBu), Lys(Dde), Lys(Alloc), Lys(Ac), Lys(Gly), {Lys(Cys)} Cys(NPys), Cys(MOB)
Cysteic acid Dansyl (Lys in sequence) Dinitrobenzoylation (Lys)
DL-Lipoic acid (N-Terminal) DTPA (N-Terminal) Fatty acid (N-Terminal)
Heptanoyl, Hexanoyl, Octanoyl Hexafluoroisopropanol solvent (HFIP) Linoleic
Lys(Bip) (Biphenylalanine) Lys(Hynic) Lys(Pen)
Lys(TMR) (middle) Methionine sulphoxide Myoglobin (sigma M5696-100MG)
N-cinnamoyl (N-terminal) NHEt (C-terminal) NHisopen (C-terminal)
OBzl (C-terminal) Oleic acid >99% Ovalbumin (sigma A5503-1G)
Palmitoylation (side chain of Cys) Perfluorodecanoic C10 Sar
Rhodamine110 TBzl (C-terminal) Thioglycerol
Tosyl (N-terminal) Tyr(3-I)/Tyr(3,5-I)/Phe(4-I) Tyr(SO3H2) - Sulfated Tyr
Methionine sulfoxid Methionine sulfone

3- Disfulfide bridge

None
Mono Disulfide bridge: Cys n° Cys n°
Double Disulfide bridge
Triple Disulfide bridge
More


4- Special analysis of your peptide

Peptide content analysis (N%)
Peptide content analysis (TFA%)
Peptide content analysis (water%)
Amino Acid Analysis (AAA) - qualitative
Endotoxin removal
Bicarbonate buffer
TFA removal / Salt Switch (Precise your requirements in comment section)
Aliquoting in vials of mg

+ Peptide array, peptide library synthesis and MAP overview
Our 96 well automated systems allow us to produce peptide arrays in a short turnaround time and at very affordable costs. Depending on the required volumes we can offer very low prices.
Multiple Antigenic Peptides or MAP are commonly used for generating monoclonal or polyclonal antibodies. It is an alternative antigen type to single peptides, native proteins, recombinant proteins or even cDNA injections. Each molecule is bound to a matrix composed by 4 or 8 lysine residues branches. One of the main advantages is that it doesn’t require any further conjugation to a BSA or KLH carrier.
A peptide library is usually composed by chemical sequences of 15 to 20 AA that cover a whole protein no matter the size. Given our high production capacity there is no limitation in protein size. One of the most popular applications is to perform antibody epitope mapping to determine precisely where an antibody binds to a protein. But one should keep in mind that it only makes sense for linear epitopes and not for conformational epitopes. It is very important to define the right parameters such as the number of overlapping amino acids for each sequence and the size of the final sequences. MAPs are also widely used for drug discovery and especially during drug target screening steps.

5- Comments and notes



   


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