Human PDL1, B7-H1, CD274 recombinant protein

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Description of Human PDL1 / B7-H1 / CD274 recombinant protein

Description of Human PDL1 / B7-H1 / CD274 recombinant protein

General Information about Human PDL1 / B7-H1 / CD274 recombinant protein

Programmed death ligand 1 (PD-L1), also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein encoded by the CD274 gene in humans. It is a member of the B7 family in the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, endothelial cells and IFN-γ activated monocytes.
Programmed Death Ligand 1 (PD-L1) is a transmembrane protein that is believed to inhibit immune system adaptation during specific events (such as pregnancy, ectopic tissue disease, autoimmune disease, and other diseases such as hepatitis). In general, the adaptive immune system reacts to antigens associated with the immune system through dangerous exogenous or endogenous activities. In turn, clonal expansion of antigen-specific CD8 + T cells and / or CD4 + helper cells is widespread. The binding of PD-L1 to the inhibitory control molecule PD-1 transmits an inhibitory signal through the interaction of a tyrosine-based immunoreceptor (ITSM) motif with phosphatase (SHP-1 or SHP-2). This reduces the proliferation of antigen-specific T cells in ganglia and at the same time reduces the apoptosis of regulatory T cells (anti-inflammatory and inhibitory T cells), further mediated by lower regulation of the Bcl-2 gene.

Product nameHuman PDL1, B7-H1, CD274 recombinant protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight28.73kDa
Purity estimated90%
Buffer50 mM Tris-HCl pH 8, 150 mM NaCl
FormLyophilized
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
Fragment TypePartial
Aliases /SynonymsPDL1, Programmed cell death 1 ligand 1, CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1-LG1, Programed Death Ligand 1
ReferencePX-P4038
NoteFor research use only
Product nameHuman PDL1, B7-H1, CD274 recombinant protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight28.73kDa
Purity estimated90%
Buffer50 mM Tris-HCl pH 8, 150 mM NaCl
FormLyophilized
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
Fragment TypePartial
Aliases /SynonymsPDL1, Programmed cell death 1 ligand 1, CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1-LG1, Programed Death Ligand 1
ReferencePX-P4038
NoteFor research use only

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