Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein

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Description of Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein

Mouse PAD4 (PADI4) functions as a transcriptional coregulator by catalyzing the conversion of histone H3 arginine residues to citrulline residues. This reaction, known as citrullination, leads to the post-translational modification of proteins.

PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility.
Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.

Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.

Product nameMouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
Uniprot IDQ9Z183
Origin speciesHouse Mouse
Molecular weight77.52kDa
Protein delivered with Tag?Yes
Purity estimated90%
Buffer50mM Tris-Cl pH 8.0, 150mM NaCl
Delivery conditionDry Ice
Delivery lead time in business days10-25
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesInsect
Spec:Entrez GeneID18602
Spec:NCBI Gene AliasesPad4, Pdi4,Padi4
NCBI ReferenceNP_035191.2
Publications1. F. Arnoux and al (2017).
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.

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