No services found
No Products found
100ug, 50ug
ProteoGenix
Recombinant Proteins
Insect
Elisa, WB
Mouse PAD4 (PADI4) functions as a transcriptional coregulator by catalyzing the conversion of histone H3 arginine residues to citrulline residues. This reaction, known as citrullination, leads to the post-translational modification of proteins.
PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility. Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.
Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.
Publication
1. F. Arnoux and al (2017).Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types. 2. Citrullination, a novel posttranslational modification of elastin, is involved in COPD pathogenesis, Mark P. Murphy, Marina Zieger, Michael Henry, Paula Meleady, Christian Mueller, Noel G. McElvaney, and Emer P. Reeves, American Journal of Physiology-Lung Cellular and Molecular Physiology 2024 327:4, L600-L606 , doi: 10.1152/ajplung.00185.2024
Reviews
There are no reviews yet.
Your email address will not be published. Required fields are marked *
Was the protein active? * Yes No
Your review *
Name *
Email *
Save my name, email, and website in this browser for the next time I comment.
Got a question or need a quote? Message us and we’ll get back to you 48 hours or less.
First name
Last name
Email address
Lab / Company
Phone number
send
Your cart is currently empty.