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Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
| Size | 10ug, 100ug |
|---|---|
| Brand | |
| Product type | |
| Host Species |
Description of Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
Description of Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein
General Information nn Mouse PAD4 :
Mouse PAD4 (PADI4) functions as a transcriptional coregulator by catalyzing the conversion of histone H3 arginine residues to citrulline residues. This reaction, known as citrullination, leads to the post-translational modification of proteins.
PADI4 gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 is mainly expressed in granulocytes, monocytes and CD34+ stem cells. Protein arginine deiminase type-4 was initially cloned from the HL-60 cell line (human promyelocytic leukemia cells). Protein arginine deiminase type-4 may play a role in granulocyte and macrophage development leading to inflammation and immune response. The PADI4 single-nucleotide polymorphism (SNP) and haplotypes were associated with rheumatoid arthritis susceptibility.
Recently, PAD4 has also been found in a variety of malignant tumors and implies its potential roles in tumor genesis.
Eukaryote expression systems and more specifically Insect cells are used at ProteoGenix to produce mouse PAD4 recombinant protein with appropriate post translational modifications.
| Product name | Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein |
|---|---|
| Origin species | House Mouse |
| Expression system | Eukaryotic expression |
| Molecular weight | 77.52kDa |
| Purity estimated | 90% |
| Buffer | 50mM Tris-Cl pH 8.0, 150mM NaCl |
| Form | Frozen |
| Delivery condition | Dry Ice |
| Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
| Brand | ProteoGenix |
| Host species | Insect |
| Fragment Type | Full-length |
| Aliases /Synonyms | Pad4, Pdi4，Padi4，Peptidylarginine deiminase IV,Protein-arginine deiminase type IV |
| Reference | PX-P4068 |
| Publications | 1. F. Arnoux and al (2017). Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types. |
| Note | For research use only |
| Product name | Mouse PAD4 protein-arginine deiminase type-4 Recombinant Protein |
|---|---|
| Origin species | House Mouse |
| Expression system | Eukaryotic expression |
| Molecular weight | 77.52kDa |
| Purity estimated | 90% |
| Buffer | 50mM Tris-Cl pH 8.0, 150mM NaCl |
| Form | Frozen |
| Delivery condition | Dry Ice |
| Storage condition | 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection) |
| Brand | ProteoGenix |
| Host species | Insect |
| Fragment Type | Full-length |
| Aliases /Synonyms | Pad4, Pdi4，Padi4，Peptidylarginine deiminase IV,Protein-arginine deiminase type IV |
| Reference | PX-P4068 |
| Publications | 1. F. Arnoux and al (2017). Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types. |
| Note | For research use only |
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