Human PAD2 arginine deiminase type-2 Recombinant Protein

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Description of Human PAD2 arginine deiminase type-2 Recombinant Protein

Description of Human PAD2 arginine deiminase type-2 Recombinant Protein

Product nameHuman PAD2 arginine deiminase type-2 Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight101.39 kDa
Purity estimated30%
BufferPBS, pH 7.5
FormFrozen
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesInsect
Fragment TypeUnknown
Aliases /SynonymsProtein-arginine deiminase type-2 Human, peptidyl arginine deiminase, type II, Protein-arginine deiminase type-2 ou PAD-H19 ou Peptidylarginine deiminase II ou Protein-arginine deiminase type II
ReferencePX-P2082
Publications1. F. Arnoux and al. (2017)
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.
NoteFor research use only
Product nameHuman PAD2 arginine deiminase type-2 Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight101.39 kDa
Purity estimated30%
BufferPBS, pH 7.5
FormFrozen
Delivery conditionDry Ice
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesInsect
Fragment TypeUnknown
Aliases /SynonymsProtein-arginine deiminase type-2 Human, peptidyl arginine deiminase, type II, Protein-arginine deiminase type-2, PAD-H19, Peptidylarginine deiminase II, Protein-arginine deiminase type II
ReferencePX-P2082
Publications1: Damgaard D, Friberg Bruun Nielsen M, Quisgaard Gaunsbaek M, Palarasah Y, Svane-Knudsen V, Nielsen CH. Smoking is associated with increased levels of extracellular peptidylarginine deiminase 2 (PAD2) in the lungs. Clin Exp Rheumatol. 2015 May-Jun;33(3):405-8. Epub 2015 Apr 16. PubMed PMID: 25897949. 2: Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem Biol. 2015 Apr 17;10(4):1043-53. doi: 10.1021/cb500933j. Epub 2015 Jan 26. PubMed PMID: 25621824; PubMed Central PMCID: PMC4569063. 3: Damgaard D, Senolt L, Nielsen MF, Pruijn GJ, Nielsen CH. Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen. Arthritis Res Ther. 2014 Dec 5;16(6):498. doi: 10.1186/s13075-014-0498-9. PubMed PMID: 25475141; PubMed Central PMCID: PMC4298085. 4: McElwee JL, Mohanan S, Horibata S, Sams KL, Anguish LJ, McLean D, Cvitaš I, Wakshlag JJ, Coonrod SA. PAD2 overexpression in transgenic mice promotes spontaneous skin neoplasia. Cancer Res. 2014 Nov 1;74(21):6306-17. doi: 10.1158/0008-5472.CAN-14-0749. Epub 2014 Sep 11. PubMed PMID: 25213324. 5: Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry. 2014 Jul 15;53(27):4426-33. doi: 10.1021/bi500554b. Epub 2014 Jul 3. PubMed PMID: 24989433; PubMed Central PMCID: PMC4100781. 6: Damgaard D, Palarasah Y, Skjødt K, Catrina AI, Hensen SM, Pruijn GJ, Nielsen CH. Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay. J Immunol Methods. 2014 Mar;405:15-22. doi: 10.1016/j.jim.2013.12.008. Epub 2013 Dec 31. PubMed PMID: 24384061. 7: Bonilha VL, Shadrach KG, Rayborn ME, Li Y, Pauer GJ, Hagstrom SA, Bhattacharya SK, Hollyfield JG. Retinal deimination and PAD2 levels in retinas from donors with age-related macular degeneration (AMD). Exp Eye Res. 2013 Jun;111:71-8. doi: 10.1016/j.exer.2013.03.017. Epub 2013 Apr 3. PubMed PMID: 23562679; PubMed Central PMCID: PMC3683981. 8: Jang B, Ishigami A, Maruyama N, Carp RI, Kim YS, Choi EK. Peptidylarginine deiminase and protein citrullination in prion diseases: strong evidence of neurodegeneration. Prion. 2013 Jan-Feb;7(1):42-6. doi: 10.4161/pri.22380. Epub 2012 Sep 28. Review. PubMed PMID: 23022892; PubMed Central PMCID: PMC3609049. 9: Cherrington BD, Zhang X, McElwee JL, Morency E, Anguish LJ, Coonrod SA. Potential role for PAD2 in gene regulation in breast cancer cells. PLoS One. 2012;7(7):e41242. doi: 10.1371/journal.pone.0041242. Epub 2012 Jul 24. PubMed PMID: 22911765; PubMed Central PMCID: PMC3404060. 10: Cherrington BD, Mohanan S, Diep AN, Fleiss R, Sudilovsky D, Anguish LJ, Coonrod SA, Wakshlag JJ. Comparative analysis of peptidylarginine deiminase-2 expression in canine, feline and human mammary tumours. J Comp Pathol. 2012 Aug-Oct;147(2-3):139-46. doi: 10.1016/j.jcpa.2012.01.021. Epub 2012 Apr 19. PubMed PMID: 22520816. 11: Calabrese R, Zampieri M, Mechelli R, Annibali V, Guastafierro T, Ciccarone F, Coarelli G, Umeton R, Salvetti M, Caiafa P. Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood. Mult Scler. 2012 Mar;18(3):299-304. doi: 10.1177/1352458511421055. Epub 2011 Aug 30. PubMed PMID: 21878453. 12: Cafaro TA, Santo S, Robles LA, Crim N, Urrets-Zavalia JA, Serra HM. Peptidylarginine deiminase type 2 is over expressed in the glaucomatous optic nerve. Mol Vis. 2010 Aug 17;16:1654-8. PubMed PMID: 20806090; PubMed Central PMCID: PMC2927370. 13: Jang B, Jin JK, Jeon YC, Cho HJ, Ishigami A, Choi KC, Carp RI, Maruyama N, Kim YS, Choi EK. Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease. Acta Neuropathol. 2010 Feb;119(2):199-210. doi: 10.1007/s00401-009-0625-x. Epub 2009 Dec 16. PubMed PMID: 20013286. 14: Hojo-Nakashima I, Sato R, Nakashima K, Hagiwara T, Yamada M. Dynamic expression of peptidylarginine deiminase 2 in human monocytic leukaemia THP-1 cells during macrophage differentiation. J Biochem. 2009 Oct;146(4):471-9. doi: 10.1093/jb/mvp097. Epub 2009 Jun 29. PubMed PMID: 19564157. 15: Watanabe Y, Nunokawa A, Kaneko N, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Itokawa M, Otowa T, Ozaki N, Someya T. A two-stage case-control association study of PADI2 with schizophrenia. J Hum Genet. 2009 Jul;54(7):430-2. doi: 10.1038/jhg.2009.52. Epub 2009 May 29. PubMed PMID: 19478818.
NoteFor research use only

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