CD132 Recombinant Protein

General information on CD132 Recombinant Protein:

The common gamma chain (γc) (or CD132), also known as the interleukin 2 receptor γ or IL2RG subunit, is a member of the type I cytokine family and is expressed in most lymphocytes (leukocytes) and its cells in mammals. A gene was found on its X chromosome. The common γ (γc) chain (or IL2RG) is the cytokine receptor subunit, which is the cytokine receptor subunit shared by the receptor complexes of at least six different interleukin receptors. IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin 21 receptors. It is a component of many cytokine receptors, which are essential for the development and function of lymphocytes. Severe X-linked combined immunodeficiency (XSCID) is a rare and life-threatening disease caused by mutations in IL2RG (the gene that encodes IL2RG). Based on chemical binding data, IL2RG has been shown to be a component of the IL-4 receptor, that is, the ability of IL2RG to increase IL-4 binding affinity. The observation that the IL-2R range is a functional part of the IL-4 receptor, and the discovery that IL-2Rγ is related to the IL-7 receptor, began to explain why the lack of this γ chain common (γc) has an impact on lymphatic development and function. It has a profound impact, as seen in X-linked severe combined immunodeficiency.