Recombinant Human RBCK1 Protein, N-His

Description of Recombinant Human RBCK1 Protein, N-His

The Structure of Recombinant Human RBCK1 Protein

Recombinant Human RBCK1 Protein is a type of protein that is produced through genetic engineering techniques in a laboratory setting. It is a recombinant protein, meaning that it is artificially created by combining genetic material from different sources. In this case, the genetic material used comes from human cells.

The structure of Recombinant Human RBCK1 Protein is made up of 528 amino acids, which are the building blocks of proteins. It has a molecular weight of approximately 60 kDa. The protein contains several functional domains, including a Ubiquitin-like domain, a Zinc finger domain, and a Ring finger domain. These domains play important roles in the activity of the protein.

The Activity of Recombinant Human RBCK1 Protein

Recombinant Human RBCK1 Protein is a key regulator of the Ubiquitin-Proteasome System (UPS), which is responsible for the degradation of proteins in the cell. The protein acts as an E3 ubiquitin ligase, which means it helps to transfer the small protein, ubiquitin, onto target proteins. This tagging with ubiquitin marks the target proteins for degradation by the proteasome.

RBCK1 has been shown to interact with various proteins involved in the UPS, such as the E2 ubiquitin-conjugating enzymes UbcH7 and UbcH8, as well as the proteasome subunit Rpn10. This interaction allows RBCK1 to play a crucial role in the regulation of protein turnover and quality control in the cell.

In addition to its role in the UPS, Recombinant Human RBCK1 Protein has also been found to be involved in other cellular processes. It has been shown to regulate the activity of the transcription factor NF-κB, which plays a critical role in immune response and inflammation. RBCK1 has also been implicated in the regulation of autophagy, a process by which cells break down and recycle damaged or unnecessary components.

The Application of Recombinant Human RBCK1 Protein

Recombinant Human RBCK1 Protein has a wide range of applications in both research and clinical settings. In research, it is commonly used as a tool to study the role of RBCK1 in various cellular processes. By manipulating the levels or activity of RBCK1, researchers can gain insights into its function and potential therapeutic applications.

In the clinical setting, Recombinant Human RBCK1 Protein has been studied as a potential therapeutic target for various diseases. Dysregulation of the UPS has been linked to several disorders, including cancer, neurodegenerative diseases, and autoimmune disorders. As RBCK1 plays a critical role in the UPS, it has been proposed as a potential target for drug development in these diseases.

Furthermore, studies have shown that RBCK1 levels are elevated in certain cancer types, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, RBCK1 has been found to be involved in the regulation of immune response, making it a potential target for immunotherapy in autoimmune disorders.

In conclusion, Recombinant Human RBCK1 Protein is a crucial player in the regulation of protein turnover and quality control in the cell. Its structure, activity, and diverse range of applications make it a valuable tool for research and a potential target for therapeutic intervention in various diseases.