Recombinant Human PHLPP1 Protein, N-His

Reference: YHA89101
Product nameRecombinant Human PHLPP1 Protein, N-His
Origin speciesHuman
Expression systemEukaryotic expression
Molecular weight30.31 kDa
BufferLyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
FormLiquid
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandAntibodySystem
Host speciesEscherichia coli (E.coli)
Fragment TypeSer1168-Thr1425
Aliases /SynonymsKIAA0606, Pleckstrin homology domain-containing family E member 1, hSCOP, PHLPP, SCOP, PHLPP1, PH domain leucine-rich repeat-containing protein phosphatase 1, PLEKHE1, Suprachiasmatic nucleus circadian oscillatory protein, PH domain-containing family E member 1
ReferenceYHA89101
NoteFor research use only.

Description of Recombinant Human PHLPP1 Protein, N-His

Introduction

Recombinant Human PHLPP1 Protein, also known as Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 1, is a human protein that plays a crucial role in regulating cellular signaling pathways. This protein is produced through the process of recombinant DNA technology, making it a valuable tool for scientific research and potential therapeutic applications.

Structure of Recombinant Human PHLPP1 Protein

The structure of Recombinant Human PHLPP1 Protein consists of two distinct domains: the N-terminal Pleckstrin Homology (PH) domain and the C-terminal Leucine-Rich Repeat (LRR) domain. The PH domain is responsible for binding to phosphoinositides, which are lipid molecules involved in cell signaling. The LRR domain, on the other hand, is involved in protein-protein interactions and plays a role in determining the substrate specificity of PHLPP1.

Recombinant Human PHLPP1 Protein is produced in a recombinant expression system, where the gene encoding for this protein is inserted into a suitable host cell, such as E. coli, and is then expressed and purified to obtain a highly pure and active protein.

Activity of Recombinant Human PHLPP1 Protein

The primary function of PHLPP1 is to act as a phosphatase, which means it removes phosphate groups from other proteins, thereby regulating their activity. Specifically, PHLPP1 is known to dephosphorylate and inactivate several key signaling molecules, such as Akt and PKC, which play important roles in cell growth, survival, and metabolism. By dephosphorylating these proteins, PHLPP1 helps to maintain a balance in cellular signaling and prevent aberrant cell growth and proliferation.

Moreover, PHLPP1 has been shown to have tumor-suppressive properties, as it can inhibit the activity of oncogenic proteins and promote cell death in cancer cells. This makes Recombinant Human PHLPP1 Protein a valuable tool for studying the mechanisms of cancer development and potentially developing therapeutic strategies for cancer treatment.

Application of Recombinant Human PHLPP1 Protein

Recombinant Human PHLPP1 Protein has a wide range of applications in scientific research, particularly in the fields of cell signaling, cancer biology, and drug discovery. Its ability to regulate the activity of key signaling molecules makes it a valuable tool for studying the mechanisms of various diseases and identifying potential therapeutic targets.

One of the main applications of Recombinant Human PHLPP1 Protein is in understanding the role of PHLPP1 in cancer development and progression. Studies have shown that PHLPP1 expression is downregulated in several types of cancer, and its overexpression can inhibit tumor growth and promote cell death. Therefore, Recombinant Human PHLPP1 Protein can be used to investigate the mechanisms underlying its tumor-suppressive properties and potentially develop new cancer treatments.

Additionally, Recombinant Human PHLPP1 Protein can also be used in drug discovery and development. As PHLPP1 plays a critical role in regulating cell signaling, it can serve as a potential drug target for various diseases, including cancer, diabetes, and cardiovascular diseases. Recombinant Human PHLPP1 Protein can be used in high-throughput screening assays to identify small molecule inhibitors that can modulate its activity, thereby providing potential leads for drug development.

Conclusion

Recombinant Human PHLPP1 Protein is a valuable tool for scientific research, with its unique structure, diverse functions, and potential applications in various fields. Its role in regulating cell signaling and its tumor-suppressive properties make it an attractive target for further studies and potential drug development. With the continuous advancements in recombinant DNA technology, Recombinant Human PHLPP1 Protein is expected to play an increasingly important role in understanding disease mechanisms and developing new

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