Recombinant Human FSIP1, N-GST

Reference: YHJ23301
Product nameRecombinant Human FSIP1, N-GST
Origin speciesHuman
Expression systemEukaryotic expression
Molecular weight54.14 kDa
BufferLyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Fragment TypeAsp55-Asp287
Aliases /SynonymsFSIP1, Fibrous sheath-interacting protein 1
NoteFor research use only.

Description of Recombinant Human FSIP1, N-GST

Structure of Recombinant Human FSIP1

Recombinant Human FSIP1, also known as Fibrous Sheath Interacting Protein 1, is a protein that is encoded by the FSIP1 gene in humans. It consists of 4,319 amino acids and has a molecular weight of approximately 483 kDa. The protein is composed of multiple domains, including an N-terminal coiled-coil domain, a central domain with multiple ankyrin repeats, and a C-terminal domain with a conserved leucine zipper motif.

The coiled-coil domain is responsible for the protein’s structural stability and is involved in protein-protein interactions. The central domain contains 18 ankyrin repeats, which are known to mediate protein-protein interactions and play a role in cell signaling and gene regulation. The C-terminal domain, on the other hand, is responsible for the protein’s dimerization and is essential for its function.

Activity of Recombinant Human FSIP1

Recombinant Human FSIP1 is a key component of the fibrous sheath, a specialized structure in the sperm tail that is essential for sperm motility. It is primarily expressed in the testis and is involved in the regulation of sperm motility and fertilization. The protein interacts with other proteins in the fibrous sheath, such as AKAP3 and AKAP4, to form a complex that is crucial for sperm motility.

In addition to its role in sperm motility, Recombinant Human FSIP1 has also been found to play a role in gene regulation. It has been shown to interact with transcription factors, such as CREB and Sp1, and regulate their activity. This suggests that the protein may have a broader role in cellular processes beyond sperm motility.

Application of Recombinant Human FSIP1

Recombinant Human FSIP1 has been widely used as a research tool to study sperm motility and fertilization. It is commonly used in in vitro studies to investigate the role of the protein in sperm function. The recombinant protein is also used to generate antibodies for immunohistochemistry and western blotting experiments, allowing for the detection and localization of FSIP1 in various tissues and cell types.

Furthermore, Recombinant Human FSIP1 has potential clinical applications in the field of assisted reproductive technology. Defects in sperm motility are a common cause of male infertility, and FSIP1 has been identified as a key player in this process. Studies have shown that mutations in the FSIP1 gene can lead to abnormal sperm motility and male infertility. Therefore, understanding the structure and function of this protein could lead to the development of new diagnostic and therapeutic strategies for male infertility.

In conclusion, Recombinant Human FSIP1 is a large and complex protein that plays a crucial role in sperm motility and fertilization. Its unique structure and diverse functions make it a valuable tool for research and have potential clinical applications in the field of male infertility. Further studies on this protein will continue to expand our understanding of its role in cellular processes and its potential as a therapeutic target.


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