Recombinant Human CCT7 Protein, N-His

Reference: YHK66801
Product nameRecombinant Human CCT7 Protein, N-His
Origin speciesHuman
Expression systemEukaryotic expression
Molecular weight57.56 kDa
BufferLyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
FormLiquid
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandAntibodySystem
Host speciesEscherichia coli (E.coli)
Fragment TypeGly18-Lys521
Aliases /SynonymsTCP-1-eta, CCT7, CCTH, HIV-1 Nef-interacting protein, NIP7-1, CCT-eta, T-complex protein 1 subunit eta
ReferenceYHK66801
NoteFor research use only.

Description of Recombinant Human CCT7 Protein, N-His

Introduction

Recombinant Human CCT7 Protein is a highly specialized protein that plays a crucial role in the proper folding and assembly of other proteins in the cell. It belongs to the chaperonin family of proteins and is also known as CCT eta or TCP-1 eta. This protein is produced using recombinant DNA technology, making it a valuable tool in various fields of research and biotechnology. In this article, we will delve into the structure, activity, and applications of Recombinant Human CCT7 Protein.

Structure of Recombinant Human CCT7 Protein

Recombinant Human CCT7 Protein is a 60 kDa protein that is composed of 547 amino acids. It is a subunit of the chaperonin-containing TCP-1 (CCT) complex, which is a large, barrel-shaped protein complex made up of eight different subunits. CCT7 is one of the two subunits that form the apical domain of the complex, which is responsible for binding to unfolded or misfolded proteins.

The structure of CCT7 is highly conserved among different species, indicating its essential role in protein folding. It contains two distinct domains, an N-terminal domain that is responsible for ATP binding and a C-terminal domain that is involved in substrate binding. The protein also has a unique protrusion loop that is thought to play a role in substrate recognition.

Activity of Recombinant Human CCT7 Protein

Recombinant Human CCT7 Protein acts as a molecular chaperone, which means it helps other proteins to fold into their correct three-dimensional structures. This is a crucial process as the proper folding of proteins is essential for their function. CCT7, along with other subunits of the CCT complex, forms a barrel-like structure that provides a protected environment for the folding of newly synthesized or damaged proteins.

CCT7 has been shown to have a preference for binding to hydrophobic regions of unfolded or misfolded proteins. It uses energy from ATP hydrolysis to bind to these regions and facilitate their folding. In addition to its role in protein folding, CCT7 has also been implicated in the assembly of protein complexes, such as actin and tubulin.

Applications of Recombinant Human CCT7 Protein

Recombinant Human CCT7 Protein has a wide range of applications in the fields of research and biotechnology. One of its key uses is in the production of recombinant proteins. As CCT7 is involved in the proper folding of proteins, it can be used to improve the yield and quality of recombinant proteins produced in bacterial, yeast, or insect cells.

CCT7 has also been studied for its potential therapeutic applications. It has been shown to play a role in the pathogenesis of certain diseases, such as cancer and neurodegenerative disorders. As such, targeting CCT7 could be a potential strategy for the development of new treatments for these diseases.

In addition, recombinant CCT7 has been used in structural biology studies to determine the structure of protein complexes and their interactions. It has also been utilized in drug discovery programs to screen for compounds that can modulate its activity.

Conclusion

In summary, Recombinant Human CCT7 Protein is a highly specialized protein with a crucial role in protein folding and assembly. Its unique structure and activity make it a valuable tool in various fields of research and biotechnology. With its potential therapeutic applications and use in drug discovery, CCT7 continues to be an important protein in the scientific community.

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