Lipase Protein- Propionibacterium Acnes LIPASE Recombinant Protein

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10ug, 100ug

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Product type

Host Species

Description of Lipase Protein/ Propionibacterium Acnes LIPASE Recombinant Protein

Description of Lipase Protein/ Propionibacterium Acnes LIPASE Recombinant Protein

General information on Lipase Protein:

Propionibacterium acnes lipase is a protein secreted by the Propionibacterium acnes which is a gram-positive anaerobic bacterium. This lipase protein metabolizes sebum which in turn results into metabolites that are responsible for the human skin condition known as acne vulgaris. It is also believed that lipase overexpression increases follicular development.
Propionibacterium acnes lipase protein acts on triglycerides to release free fatty acids. Among the fatty acids released, Palmitic acid stimulates the toll-like receptor 2-mediated inflammasome. The latter is associated with the release of interleukin-1, Th17 differenciation and interleukin-17-mediated keratinocyte proliferation. Oleic acid, another fatty acid released stimulates adhesion and keratinocyte proliferation in Propionibacterium acnes, also via the release of interleukin-1.
Antifugal drug ketoconazole has been suggested to inhibit P.acnes lipase activity. However, the mechanism by which ketoconazole inhibits P.acnes lipase protein remains unknown.

Product nameLipase Protein- Propionibacterium Acnes LIPASE Recombinant Protein
Origin speciesPropionibacterium acnes
Expression systemProcaryotic expression
Molecular weight34,73 kDa
Purity estimated>95%
BufferPBS pH7.5, DTT 1mM, 0.5mM Zwittergent 3-14 and 10% Glycerol if refolding. PBS, Urea 8M if denaturing conditions
Formliquid
Delivery conditionDry Ice
Storage condition

Lipase protein is stored:


At 4°C for short term period (less than a week)
At -20°C or -80°C for long term period

Recommendations


It is important to avoid avoid freezing/thawing cycles
20-40% glycerol may be added to improve cryoprotection
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
Fragment TypePartial
Aliases /SynonymsLIPASE, triacylglycerol lipase precursor
ReferencePX-P1121
NoteFor research use only
Product nameLipase Protein- Propionibacterium Acnes LIPASE Recombinant Protein
Origin speciesPropionibacterium acnes
Expression systemProcaryotic expression
Molecular weight34,73 kDa
Purity estimated>95%
BufferPBS pH7.5, DTT 1mM, 0.5mM Zwittergent 3-14 and 10% Glycerol if refolding. PBS, Urea 8M if denaturing conditions
Formliquid
Delivery conditionDry Ice
Storage condition

Lipase protein is stored:


At 4°C for short term period (less than a week)
At -20°C or -80°C for long term period

Recommendations


It is important to avoid avoid freezing/thawing cycles
20-40% glycerol may be added to improve cryoprotection
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
Fragment TypePartial
Aliases /SynonymsLIPASE, triacylglycerol lipase precursor
ReferencePX-P1121
NoteFor research use only

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