Human PARP1 Recombinant Protein


Product type

Host Species



Description of Human PARP1 Recombinant Protein

Product nameHuman PARP1 Recombinant Protein
Uniprot IDP09874
Uniprot link
Origin speciesHomo sapiens (Human)
Expression systemProcaryotic expression
Molecular weight90,90 kDa
Purity estimated60%
BufferPBS, imidazole 300mM
Delivery conditionDry Ice
Delivery lead time in business days2-3
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Fragment TypePartial
Protein AccessionAAB59447.1
Spec:Entrez GeneID142
NCBI ReferenceAAB59447.1
Aliases /SynonymsPARP1, poly(ADP-ribose) synthetase, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD(+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, ADPRT, PPOL
Publications1: Sander Effron S, Makvandi M, Lin L, Xu K, Li S, Lee H, Hou C, Pryma DA, Koch C, Mach RH. PARP-1 Expression Quantified by [(18)F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy. Cancer Biother Radiopharm. 2017 Feb;32(1):9-15. doi: 10.1089/cbr.2016.2133. Epub 2017 Jan 24. PubMed PMID: 28118040; PubMed Central PMCID: PMC5312613. 2: Cui NH, Qiao C, Chang XK, Wei L. Associations of PARP-1 variant rs1136410 with PARP activities, oxidative DNA damage, and the risk of age-related cataract in a Chinese Han population: A two-stage case-control analysis. Gene. 2017 Feb 5;600:70-76. doi: 10.1016/j.gene.2016.11.019. Epub 2016 Nov 10. PubMed PMID: 27840165. 3: Alhadheq AM, Purusottapatnam Shaik J, Alamri A, Aljebreen AM, Alharbi O, Almadi MA, Alhadeq F, Azzam NA, Semlali A, Alanazi M, Bazzi MD, Reddy Parine N. The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort. Dis Markers. 2016;2016:8289293. Epub 2016 Sep 25. PubMed PMID: 27746584; PubMed Central PMCID: PMC5055945. 4: Li S, Cui Z, Meng X. Knockdown of PARP-1 Inhibits Proliferation and ERK Signals, Increasing Drug Sensitivity in Osteosarcoma U2OS Cells. Oncol Res. 2016;24(4):279-86. doi: 10.3727/096504016X14666990347554. PubMed PMID: 27656839. 5: Anil S, Gopikrishnan PB, Basheer AB, Vidyullatha BG, Alogaibi YA, Chalisserry EP, Javed F, Dalati MH, Vellappally S, Hashem MI, Divakar DD. Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population. Asian Pac J Cancer Prev. 2016;17(8):4107-11. PubMed PMID: 27644669. 6: Mishra D, Singh S, Narayan G. Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage. Asian Pac J Cancer Prev. 2016;17(8):3865-9. PubMed PMID: 27644631. 7: Gallo M, Cacheux V, Vincent L, Bret C, Tempier A, Guittard C, Macé A, Leventoux N, Costes V, Szablewski V. Leukemic non-nodal mantle cell lymphomas have a distinct phenotype and are associated with deletion of PARP1 and 13q14. Virchows Arch. 2016 Dec;469(6):697-706. Epub 2016 Sep 7. PubMed PMID: 27605053. 8: Jubin T, Kadam A, Jariwala M, Bhatt S, Sutariya S, Gani AR, Gautam S, Begum R. The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival. Cell Prolif. 2016 Aug;49(4):421-37. doi: 10.1111/cpr.12268. Epub 2016 Jun 22. Review. PubMed PMID: 27329285. 9: Nogueira A, Assis J, Faustino I, Pereira D, Catarino R, Medeiros R. Base excision repair pathway: PARP1 genotypes as modulators of therapy response in cervical cancer patients. Biomarkers. 2017 Feb;22(1):70-76. doi: 10.1080/1354750X.2016.1204006. Epub 2016 Jul 6. PubMed PMID: 27323894. 10: Wang L, Liu F, Jiang N, Zhou W, Zhou X, Zheng Z. Design, Synthesis, and Biological Evaluation of Novel PARP-1 Inhibitors Based on a 1H-Thieno[3,4-d] Imidazole-4-Carboxamide Scaffold. Molecules. 2016 Jun 13;21(6). pii: E772. doi: 10.3390/molecules21060772. PubMed PMID: 27304949. 11: Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353(6294):45-50. doi: 10.1126/science.aaf7865. Epub 2016 Jun 2. PubMed PMID: 27256882. 12: Zeng J, Libien J, Shaik F, Wolk J, Hernández AI. Nucleolar PARP-1 Expression Is Decreased in Alzheimer's Disease: Consequences for Epigenetic Regulation of rDNA and Cognition. Neural Plast. 2016;2016:8987928. doi: 10.1155/2016/8987928. Epub 2016 Feb 29. PubMed PMID: 27034851; PubMed Central PMCID: PMC4789469. 13: Li Z, Lv T, Liu Y, Huang X, Qiu Z, Li J. PARP1 is a novel independent prognostic factor for the poor prognosis of chordoma. Cancer Biomark. 2016 Mar 18;16(4):633-9. doi: 10.3233/CBM-160605. PubMed PMID: 27002766. 14: Salluzzo MG, Cosentino FI, Romano C, Scillato F, Morale MC, Rando RG, Elia F, Spada RS, Bosco P, Salemi M. Poly (ADP-ribose) polymerase-1 (PARP-1) -410C/T polymorphism in Sicilian patients with Parkinson's disease. J Neurol Sci. 2016 Apr 15;363:95-6. doi: 10.1016/j.jns.2016.02.039. Epub 2016 Feb 17. PubMed PMID: 27000229. 15: Deben C, Lardon F, Wouters A, Op de Beeck K, Van den Bossche J, Jacobs J, Van Der Steen N, Peeters M, Rolfo C, Deschoolmeester V, Pauwels P. APR-246 (PRIMA-1(MET)) strongly synergizes with AZD2281 (olaparib) induced PARP inhibition to induce apoptosis in non-small cell lung cancer cell lines. Cancer Lett. 2016 Jun 1;375(2):313-22. doi: 10.1016/j.canlet.2016.03.017. Epub 2016 Mar 11. PubMed PMID: 26975633.
NoteFor research use only


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