CD253 Recombinant Protein

Reference: PX-P4111-100



Product type

Host Species

Description of CD253 Recombinant Protein

General Information about CD253 Recombinant Protein

Recombinant human CD253 is a 19.6 kDa protein consisting of 168 amino acids, corresponding to the TNF homologous region of the human TRAIL / ApoL2 extracellular domain. TNF-induced ligand apoptosis (TRAIL) is expressed in many tissues including spleen, lung, and prostate and can induce apoptosis depending on specific tumors. Apoptosis begins with the combination of two death receptors DR4 and DR5, which trigger cell death through the Caspian cascade. However, there are two types of ornamental receptors DcR1 and DcR2 that competitively bind to CD253, but do not induce apoptosis. The possible use of TRAIL as a therapeutic anticancer agent has been confirmed in numerous studies, which have shown that about two thirds of the tumor cell lines tested have tumoricidal activity. Recombinant human CD253 is a rabbit immunogen used to produce anti-human CD253.

Product nameCD253 Recombinant Protein
Origin speciesHomo sapiens (Human)
Expression systemProcaryotic expression
Molecular weight33.78kDa
Purity estimated>90% by SDS-PAGE
BufferC-terminal His Tag
Delivery conditionDry Ice
Storage conditionStore at - 20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage.
Host speciesEscherichia coli (E.coli)
Fragment TypeMet1~Gly281
Aliases /SynonymsAPO2L, TRAIL
NoteFor research use only


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