CD122 Recombinant Protein

Reference: PX-P4103-100
Product nameCD122 Recombinant Protein
Uniprot IDP14784
Uniprot link
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
Molecular weight35-45kDa
Protein delivered with Tag?C-terminal His Tag
Purity estimated>90% by SDS-PAGE
BufferPBS pH7.5
Delivery conditionDry Ice
Storage conditionStore at - 20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage.
Host speciesMammalian cells
Fragment TypeMet1-Asp239
Aliases /SynonymsIL2RB
NoteFor research use only

Description of CD122 Recombinant Protein

General information on CD122 Recombinant Protein:

The interleukin-2 receptor (IL-2R), also known as the β subunit receptor of the β subunit IL-2, subunit of the IL-2 β and IL-2RB receptor, participates in the immune response of T cells. ability to bind interleukin 2, CD122 / IL-2RB exists in three forms. The low affinity form is a monomer of the alpha subunit and does not participate in signal transmission. The intermediate affine form is composed of α / β subunit heterodimers, while the high affinity form is composed of α / β / gamma heterotrimers. Both forms of medium and high affinity for CD122 / IL-2RB are involved in receptor-mediated endocytosis and interleukin-2-mediated mitotic signal transduction. CD122 / IL-2RB expression is limited to older B22 + cells (CD43 + CD24- prepro B cells, fraction A), which can proliferate to IL-2 strongly without any stromal cells, but not to IL-15 A High affinity form of the receptor is expressed in activated T lymphocytes, activated B lymphocytes and activated macrophages. CD122 / IL-2RB plays a role in regulating normal lymphocyte development.


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