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Struggling with protein aggregation and inclusion bodies? Or you might just not have the tools to express a soluble protein? Discover the features of our soluble protein expression services and get the most of our expertise to reach your goals. Benefit from a complete package, from gene design to protein purification and quality control analysis at any scale required!
Pilot Study for Optimized Protocol
Benefit from a small-scale
pilot study for optimized
5 Expression Systems
5 expression systems to suit
any soluble protein
Decide whether to continue
your project or not after the
High Throughput Expression Screening
A challenging protein
expression? Benefit from our
HTP protein expression service.
ProteoGenix is your partner
from gene synthesis to
Protein Expression Expertise
Benefit from more than
28 years of experience in
Small- to Large-Scale Production
From small shake flasks to
150L bioreactors, with
protein yields reaching grams per liter.
Ph.D. Account Managers
Get advice from our Ph.D.
Each project is unique! With five different expression systems, ProteoGenix creates custom solutions to meet your goals. Each protein expression project includes an optimization phase, where several parameters are tested at a small-scale to guarantee a successful protein expression project.
With more than 7000 successful soluble protein expression projects and more than 28 years of experience, you can count on our team to overcome your most difficult challenges.
Does your new project require a soluble protein?
Discover our services!
Thanks to continuous advances in the biotechnological field, recombinant protein expression proved its efficiency as a versatile tool in research as well as in innovative drug discovery. In this context, higher production efficiencies are needed to fulfill the increasing demands on this market. Yet, overexpressed proteins can be challenging as they tend to form insoluble aggregates, so-called inclusion bodies. This phenomenon usually correlates with the loss of protein activity and poor yields.
Today, several protein expression hosts are available (bacterial, yeast, insect, mammalian). However,E.coli is usually the most used expression system. The latter constitutes an easy and inexpensive factory along with its ability to provide high yields. On the other hand, E.coli and other bacterial expression systems tend to form insoluble aggregates due to poor protein folding. For this reason, some industries prefer using mammalian cells to limit this side effect when it comes to complex proteins.
Here are some common methods to enhance protein solubility and yields in both eukaryotic and prokaryotic systems:
Get closer to your objectives and secure your investment in trustworthy soluble protein expression services.
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