What are co-inhibitory receptors?

Co-inhibitory receptors are immune cell surface proteins that transmit signals limiting immune activation. They help prevent excessive immune responses and support immune tolerance.

What are co-stimulatory receptors?

Co-stimulatory receptors provide activating signals that support T cell proliferation, survival and effector functions after antigen recognition.

Which targets are commonly studied?

Frequently studied targets include PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, CD28, CD80, CD86, ICOS, OX40 and 4-1BB.

Which reagent format should I choose?

Choose primary antibodies for detection, recombinant proteins for binding or assay development, research-grade biosimilars for reference studies and VHH antibodies when a compact binder format is preferred.

What should I check before ordering?

Check the target name, species reactivity, clone, host, isotype, format, application, product size, storage conditions and stock availability.

Which expression system is recommended for immune checkpoint proteins?

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Can ProteoGenix produce proteins that are not listed in the catalog?

Yes. We routinely develop custom recombinant proteins for novel immune checkpoints, engineered variants, mutant constructs, Fc fusion proteins and other specialized formats designed around the needs of individual research projects.

Co-inhibitory & Co-stimulatory receptors

Validated Reagents for Reliable Immune Checkpoint Research

Explore our validated range of primary antibodies, research-grade biosimilars and VHH antibodies targeting key co-inhibitory and co-stimulatory receptors, with products ready to ship.

Save 20% on this selection. Use code ONCO20. Valid until September 15

Dog CD274 recombinant protein
- PX-P6467
Host species:

Mammalian cells

Origin species:

Dog

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €265.00.Current price is: €223.00.
+ 223 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Domvanalimab Biosimilar - Anti-TIGIT mAb - Research Grade
- PX-TA1659
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €179.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Emfizatamab Biosimilar - Anti-CD3e,CD19,CD274,TNFRSF9 mAb - Research Grade
- PX-TA1893
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

scFv-G1-scFv-scFv, L-kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €189.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Encelimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade
- PX-TA1586
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €185.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Enristomig Biosimilar - Anti-Tumor necrosis factor receptor superfamily member 9; CD274 mAb - Research Grade
- PX-TA2116
- Validated ELISA WB
Clonality:

Monoclonal Antibody

Isotype:

Ig VH-VH'-G1(h-CH2-CH3)

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €192.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Envafolimab Biosimilar - Anti-CD274, PD-L1, B7-H1 mAb - Research Grade
- PX-TA1575
- Validated ELISA FC
Clonality:

Monoclonal Antibody

Isotype:

(VH-CH2-CH3)2

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €181.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Envafolimab Biosimilar - Research Grade mAb
- PX-TA1575-d
- Validated ELISA FC
Clonality:

Monoclonal antibody

Isotype:

(VH-CH2-CH3)2

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €193.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Erfonrilimab Biosimilar - Anti-CD274;CTLA4 mAb - Research Grade
- PX-TA1665
Clonality:

Monoclonal Antibody

Isotype:

Bispecific Single Domains (VH-VH'-CH),IgG1na;na

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €186.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Etigilimab Biosimilar - Anti-TIGIT, VSTM3 mAb - Research Grade
- PX-TA1507
- Validated ELISA FC
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €181.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Evalstotug Biosimilar - Anti-CD152 mAb - Research Grade
- PX-TA2117
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €179.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Favezelimab Biosimilar - Anti-LAG3 mAb - Research Grade
- PX-TA1838
- Validated ELISA FC
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €188.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Fetrastobart Biosimilar - Research Grade
- PX-TA2479
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €176.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Fianlimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade
- PX-TA1588
- Validated ELISA FC
Clonality:

Monoclonal Antibody

Isotype:

IgG4, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €174.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Firastotug Biosimilar - Anti-CD152 mAb - Research Grade
- PX-TA1948
- Validated ELISA
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €185.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Futermestotug Biosimilar - Research Grade
- PX-TA2368
Clonality:

Monoclonal antibody

Host species:

Mammalian cells

Isotype:

IgG1, Kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €192.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page
Garivulimab Biosimilar - Anti-CD274 mAb - Research Grade
- PX-TA1669
Clonality:

Monoclonal Antibody

Isotype:

IgG1, kappa

Brand:

ProteoGenix

Size:

100ug, 1MG, 50ug
Original price was: €169.00.Current price is: €140.00.
+ 140 loyalty points

In Stock Select options This product has multiple variants. The options may be chosen on the product page

Co-inhibitory & Co-stimulatory Receptors

Researchers investigating immune regulation rely on co-inhibitory and co-stimulatory receptors to understand T cell activation, immune tolerance, cancer immunotherapy, autoimmune diseases, infectious diseases, and cell therapy development. Collectively, these molecules constitute the immune checkpoint pathways that regulate immune responses and have become central targets in immunology and immuno-oncology research.

ProteoGenix provides recombinant proteins and custom protein production services covering a broad range of immune checkpoint molecules and co-signaling receptors, supporting research from early discovery through preclinical development.

Representative Immune Checkpoint Targets

Immune checkpoint research encompasses a broad network of co-inhibitory and co-stimulatory receptors involved in regulating immune activation and tolerance. Below is a representative selection of targets available through ProteoGenix.

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Not all immune checkpoint molecules are commercially available in the format required for your study. Our scientists can design and produce custom recombinant proteins, antibodies, Fc-fusion constructs, tagged proteins and engineered variants tailored to your experimental needs.

Explore Custom Protein Production

Supporting Every Stage of Immune Checkpoint Research

Whether your objective is basic immunology research or therapeutic development, selecting the appropriate recombinant protein is essential for obtaining reliable experimental results.

Our products are routinely used for applications including:

- Receptor-ligand interaction studies
- Antibody screening and characterization
- ELISA development and validation
- Surface Plasmon Resonance (SPR)
- Bio-Layer Interferometry (BLI)
- Cell-based functional assays
- Flow cytometry assay development
- Biomarker validation
- Structural biology
- Immunotherapy target evaluation
- CAR-T and TCR research
- Drug discovery programs

FAQ

Many co-inhibitory and co-stimulatory receptors are glycoproteins that benefit from mammalian expression systems such as HEK293 or CHO cells. These systems help preserve native folding and post-translational modifications that are important for biological activity.

Trusted Worldwide

Why Researchers Trust ProteoGenix

From validated reagents for co-signaling receptor research to custom antibody development, recombinant production and technical support, ProteoGenix helps researchers move faster from target selection to reliable experimental results.

Scientific & Technical Support

Get expert support for product selection, format comparison, application fit and troubleshooting when your experiment requires more than a catalog search.
Quality Assurance

Rigorous QC protocols with batch-specific certificates of analysis, lot-to-lot consistency, and ISO-certified manufacturing.
Custom Solutions

From antibody production to protein expression, we offer end-to-end custom development tailored to your research objectives.
Global Delivery

Reliable cold-chain logistics worldwide with temperature-controlled shipping and tracking for sensitive biological reagents.

Co-inhibitory & Co-stimulatory receptors

Dog CD274 recombinant protein

Domvanalimab Biosimilar - Anti-TIGIT mAb - Research Grade

Emfizatamab Biosimilar - Anti-CD3e,CD19,CD274,TNFRSF9 mAb - Research Grade

Encelimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade

Enristomig Biosimilar - Anti-Tumor necrosis factor receptor superfamily member 9; CD274 mAb - Research Grade

Envafolimab Biosimilar - Anti-CD274, PD-L1, B7-H1 mAb - Research Grade

Envafolimab Biosimilar - Research Grade mAb

Erfonrilimab Biosimilar - Anti-CD274;CTLA4 mAb - Research Grade

Etigilimab Biosimilar - Anti-TIGIT, VSTM3 mAb - Research Grade

Evalstotug Biosimilar - Anti-CD152 mAb - Research Grade

Favezelimab Biosimilar - Anti-LAG3 mAb - Research Grade

Fetrastobart Biosimilar - Research Grade

Fianlimab Biosimilar - Anti-LAG3, CD223 mAb - Research Grade

Firastotug Biosimilar - Anti-CD152 mAb - Research Grade

Futermestotug Biosimilar - Research Grade

Garivulimab Biosimilar - Anti-CD274 mAb - Research Grade

Top Products

Anti-Human TREM2 VHH (SAA1136)

Anti-Human CD354/TREM1 (PY159)

Anti-Mouse CD283/TLR3 Polyclonal Antibody

Atezolizumab Biosimilar – Anti-CD274, B7-H1, PDL1 mAb – Research Grade

Representative Immune Checkpoint Targets

Frequently studied co-inhibitory receptors

Frequently studied co-stimulatory receptors

Can’t find your target?

Supporting Every Stage of Immune Checkpoint Research

FAQ

Why Researchers Trust ProteoGenix

Scientific & Technical Support

Quality Assurance

Custom Solutions

Global Delivery

Need a quote or more information? Contact us!

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