Sacituzumab Biosimilar – Anti-TACSTD2 mAb – Research Grade

Description of Sacituzumab Biosimilar - Anti-TACSTD2 mAb - Research Grade

Sacituzumab Biosimilar – Anti-TACSTD2 mAb: A Promising Therapeutic Antibody Targeting TACSTD2 Sacituzumab Biosimilar, also known as Anti-TACSTD2 mAb, is a monoclonal antibody that has shown promising results in targeting TACSTD2, a cell surface protein that is overexpressed in various types of cancer. This biosimilar is a highly specific and potent therapeutic agent that has the potential to revolutionize cancer treatment.

Structure of Sacituzumab Biosimilar

Sacituzumab Biosimilar is a chimeric monoclonal antibody, meaning it is composed of both human and mouse components. The antibody is made up of two heavy chains and two light chains, with a total molecular weight of approximately 150 kDa. The heavy chains are composed of constant and variable regions, while the light chains only have variable regions. The variable regions are responsible for recognizing and binding to the target protein, TACSTD2.

The constant regions of Sacituzumab Biosimilar are derived from human antibodies, which reduces the likelihood of immune reactions in patients. The variable regions, on the other hand, are derived from mouse antibodies, which provides the antibody with high affinity and specificity for TACSTD2.

Activity of Sacituzumab Biosimilar

Sacituzumab Biosimilar works by binding to TACSTD2 on the surface of cancer cells, leading to a cascade of events that ultimately results in the destruction of these cells. The binding of the antibody to TACSTD2 triggers the immune system to attack and kill the cancer cells. Additionally, Sacituzumab Biosimilar also blocks the signaling pathways that promote cancer cell growth and survival, further inhibiting tumor growth.

Studies have shown that Sacituzumab Biosimilar has a high binding affinity for TACSTD2, making it a potent therapeutic agent. It has also been found to have minimal off-target effects, meaning it specifically targets cancer cells without harming healthy cells.

Application of Sacituzumab Biosimilar

Sacituzumab Biosimilar has shown promising results in preclinical and clinical studies for the treatment of various types of cancer, including breast, lung, and colorectal cancer. It has also shown potential in treating other types of solid tumors that overexpress TACSTD2.

The biosimilar is currently being evaluated in phase III clinical trials for the treatment of metastatic triple-negative breast cancer, a type of breast cancer that has limited treatment options. It has also shown promising results in early clinical trials for the treatment of other types of cancer.

In addition to its potential as a standalone therapy, Sacituzumab Biosimilar also has the potential to be used in combination with other cancer treatments, such as chemotherapy and radiation therapy. This could potentially enhance the efficacy of these treatments and improve patient outcomes.

Conclusion

Sacituzumab Biosimilar, also known as Anti-TACSTD2 mAb, is a highly specific and potent therapeutic antibody that targets the cell surface protein TACSTD2. Its unique structure and mechanism of action make it a promising treatment option for various types of cancer. With ongoing clinical trials and further research, Sacituzumab Biosimilar has the potential to significantly improve cancer treatment and patient outcomes.

SDS-PAGE for Sacituzumab Biosimilar - Anti-TACSTD2 mAb

Sacituzumab Biosimilar - Anti-TACSTD2 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.

Immobilized Tumor-associated calcium signal transducer 2(TACSTD2) (cat. No.PX-P4569) at 0.5µg/mL (100µL/well) can bind to Sacituzumab Biosimilar - Anti-TACSTD2 mAb (cat. No.PX-TA1447) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450