Brand: ProteoGenix

TNFa / TNF-alpha, N-His, recombinant protein

PX-P5961-100
Quality Chart

Host species:: Mammalian cells
Origin species:: Homo sapiens (Human)
Molecular weight:: 25.65 kDa

€319.00

100ug + 319 loyalty points

His Val77–Leu233

First Name This field is required. Last Name This field is required. Email This field is required. Company This field is required. Country This field is required. State This field is required.

In Stock
Free shipping in EU on orders > €500
Wide range of unique reagents
Fast worldwide delivery

TNFa / TNF-alpha, N-His, recombinant protein

Product name	TNFa / TNF-alpha, N-His, recombinant protein
Origin species	Homo sapiens (Human)
Expression system	Eukaryotic expression
Molecular weight	25.65 kDa
Protein delivered with Tag?	N-terminal His Tag
Purity estimated	>90% as determined by SDS-PAGE
Buffer	PBS, pH7.5
Delivery condition	Dry Ice
Storage condition	4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand	ProteoGenix
Host species	Mammalian cells
Fragment Type	Val77-Leu233
Protein Accession	P01375
Aliases /Synonyms	cachexin, cachectin
Reference	PX-P5961
Note	For research use only
Molecular Constructor	His Val77–Leu233

General information on TNFa / TNF-alpha, N-His, recombinant protein

TNF-Alpha: Cytokine Protein

TNF-alpha, also known as tumor necrosis factor-alpha, is a cytokine protein produced mainly by macrophages and other white blood cells. It is involved in the regulation of immune responses, inflammation, and cell death. TNF-alpha binds to two receptors, TNFR1 and TNFR2, which are present on the surface of many cell types. Binding to TNFR1 activates the pro-inflammatory signals, while binding to TNFR2 leads to cell death.

TNF-Alpha: Antibody-Drug Target

TNF-alpha is a target for antibody-drugs used to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn’s disease. These drugs are monoclonal antibodies that bind to TNF-alpha and inhibit its activity, thus reducing inflammation and preventing tissue damage. Infliximab and adalimumab are two of the most commonly used TNF-alpha inhibitors.

TNF-Alpha: Application

TNF-alpha has also been studied for its potential therapeutic applications. It has been used in cancer therapy to induce apoptosis in tumor cells, and it has been studied as a potential treatment for HIV infection.

SDS-PAGE for TNFa / TNF-alpha, N-His, recombinant protein

TNFa / TNF-alpha, N-His, recombinant protein on SDS-PAGE under reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is superior than 90 %.

Etanercept Biosimilar - Anti-TNF mAb binds to TNFa / TNF-alpha, N-His, recombinant protein in indirect ELISA Assay

Immobilized TNFa / TNF-alpha, N-His, recombinant protein (cat. No.PX-P5961) at 0.5µg/mL (100µL/well) can bind to Etanercept Biosimilar - Anti-TNF mAb (cat. No.PX-TA1015) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450

There are no reviews yet.

Be the first to review “TNFa / TNF-alpha, N-His, recombinant protein”

TNFa / TNF-alpha, N-His, recombinant protein

TNFa / TNF-alpha, N-His, recombinant protein