Nipah virus(HeV) -Fusion glycoprotein F0 recombinant protein

Description of Nipah virus(HeV) -Fusion glycoprotein F0 recombinant protein

Nipah Virus (HeV) Structure

Nipah virus (HeV) is a negative-sense, single-stranded RNA virus belonging to the family Paramyxoviridae. It is composed of a nucleocapsid core surrounded by a lipid envelope and a matrix protein. Its genome is 15,000 nucleotides in length, and it encodes six structural proteins and four non-structural proteins.

Nipah Virus (HeV) Activity

The activity of the Nipah virus (HeV) is mediated by its structural proteins. The F and G glycoproteins form the virus’ fusion complex, allowing it to enter host cells and fuse with the host cell membrane. The matrix protein M is involved in viral assembly and budding from the host cell. The nucleocapsid protein N is involved in the formation of the viral ribonucleoprotein complex.

Nipah Virus (HeV) Drug Target

The F fusion glycoprotein F0 is a potential drug target for Nipah virus (HeV). This protein is essential for the virus’ entry into host cells and is a promising target for vaccine and therapeutic strategies. Inhibition of the F0 glycoprotein could prevent the virus from entering host cells, thus preventing infection.