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Brand: ProteoGenix

Narsoplimab Biosimilar – Anti-MASP2 mAb – Research Grade

Isotype:
IgG4, lambda

Original price was: €169.00.Current price is: €140.00.

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SDS-PAGE for Narsoplimab Biosimilar - Anti-MASP2 mAb
Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade binds to Recombinant Human MASP2 Protein, N-His in ELISA Assay
Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade

Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade

Product name Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade
Uniprot ID O00187
Source CAS 2108782-45-0
Species Homo sapiens
Expression system Mammalian cells
Raw Antigen Sequence MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
Purity >85%
Buffer PBS buffer PH7.5
Delivery condition Blue ice (+4°C)
Delivery lead time in business days 3-5 days if in stock; 3-5 weeks if production needed
Delivery Time 3-5 days if in stock; 3-5 weeks if production needed
Storage condition store at -80°C
Brand ProteoGenix
Applications ELISA,WB
Aliases /Synonyms Narsoplimab ,OMS721,MASP2,anti-MASP2
Reference PX-TA1495
Note For research use only. Not suitable for clinical or therapeutic use.
Isotype IgG4-lambda
Clonality Monoclonal Antibody
Product name Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade
Uniprot ID O00187
Source CAS 2108782-45-0
Species Homo sapiens
Expression system Mammalian cells
Raw Antigen Sequence MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
Purity >85%
Buffer PBS buffer PH7.5
Delivery condition Blue ice (+4°C)
Delivery lead time in business days 3-5 days if in stock; 3-5 weeks if production needed
Delivery Time 3-5 days if in stock; 3-5 weeks if production needed
Storage condition store at -80°C
Brand ProteoGenix
Applications ELISA,WB,,,
Aliases /Synonyms Narsoplimab ,OMS721,MASP2,anti-MASP2
Reference PX-TA1495
Note For research use only. Not suitable for clinical or therapeutic use.
Isotype IgG4-lambda
Clonality Monoclonal Antibody
Product name PX-TA1495-50
Uniprot ID O00187
Source CAS 2108782-45-0
Species Homo sapiens
Expression system Mammalian cells
Raw Antigen Sequence MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
Purity >85%
Buffer PBS buffer PH7.5
Delivery condition Blue ice (+4°C)
Delivery lead time in business days 3-5 days if in stock; 3-5 weeks if production needed
Delivery Time 3-5 days if in stock; 3-5 weeks if production needed
Storage condition store at -80°C
Brand ProteoGenix
Aliases /Synonyms Narsoplimab ,OMS721,MASP2,anti-MASP2
Reference PX-TA1495
Note For research use only. Not suitable for clinical or therapeutic use.
Isotype IgG4, lambda

Narsoplimab Biosimilar – Anti-MASP2 mAb

About Narsoplimab biosimilar

Narsoplimab is a human monoclonal antibody. This biosimilar belong to the family of immunoglobulin G4- type. It is targeting mannan-binding lectin-associated serine protease-2 (MASP-2). This enzyme is the effector of the lectin pathway of the complement system. Narsoplimab is designed to prevent complement-mediated inflammation, but also endothelial damage, whitout interactions with other pathways of innate immunity. Indeed, Narsoplimab is developed to be a treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA).

Narsoplimab’s action

The lectin pathway is first activated by tissue damage and microbial infection. It is one of the principal pathways of complement system. Fortunately, inhibition of MASP-2 seems not to interfere with the classical complement pathway, which could be critical in the acquired immune response to infection.
Hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) is a complication of stem cell transplantation, which is often lethal. HSCT-TMA is a multifactorial disorder which is caused by endothelial cell damage. These could be induced by conditioning regimens, immunosuppressant therapies, infection, graft-versus-host disease, and every factor associated with stem cell transplantation.

A research grade biosimilar

Narsoplimab biosimilar is a human antibody produced in mammalian cell line (Chinese Hamster Ovary -CHO) using a recombinant DNA technology. Proteogenix offer a product for research use only, not suitable for clinical or therapeutic use.

SDS-PAGE for Narsoplimab Biosimilar - Anti-MASP2 mAb

SDS-PAGE for Narsoplimab Biosimilar - Anti-MASP2 mAb

Narsoplimab Biosimilar - Anti-MASP2 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.

Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade binds to Recombinant Human MASP2 Protein, N-His in ELISA Assay

Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade binds to Recombinant Human MASP2 Protein, N-His in ELISA Assay

Recombinant Human MASP2 Protein, N-His(cat. No.ARO-P12684) at 0.5µg/mL (100µL/well) can bind Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade in indirect ELISA with Goat secondary antibody measured by OD450.

Narsoplimab Biosimilar - Anti-MASP2 mAb - Research Grade

  • Kainulainen MH, Harmon JR, Bergeron É, Davies KA, LeBlanc ML, Clines C, Bentz ML, Montgomery JM, Spiropoulou CF. 0. Monoclonal IgM antibodies mediate potent complement neutralization by targeting cell-derived epitopes on enveloped viruses. mBio 0:e01709-25.https://doi.org/10.1128/mbio.01709-25

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