Elotuzumab Biosimilar – Anti-SLAMF7, CD319 mAb – Research Grade

Description of Elotuzumab Biosimilar - Anti-SLAMF7, CD319 mAb - Research Grade

Introduction

Elotuzumab Biosimilar, also known as Anti-SLAMF7 or CD319 monoclonal antibody, is a research grade therapeutic antibody that is currently being studied for its potential use in the treatment of multiple myeloma. This antibody specifically targets the SLAMF7 protein, which is overexpressed in multiple myeloma cells, making it a promising therapeutic target.

Structure of Elotuzumab Biosimilar

Elotuzumab Biosimilar is a humanized monoclonal antibody, meaning it is derived from human cells and has been modified to have a high affinity for SLAMF7. It is composed of two heavy chains and two light chains, each with a specific sequence of amino acids that determine its binding specificity. The antibody has a molecular weight of approximately 148 kDa and a half-life of 14 days.

Mechanism of Action

The primary mechanism of action of Elotuzumab Biosimilar is through its binding to SLAMF7 on the surface of multiple myeloma cells. This binding leads to the activation of natural killer (NK) cells and macrophages, which are part of the body’s immune system and play a crucial role in fighting cancer cells. The activated NK cells and macrophages then target and destroy the multiple myeloma cells, leading to tumor regression.

Research and Clinical Trials

Elotuzumab Biosimilar has been extensively studied in preclinical and clinical trials for its potential use in the treatment of multiple myeloma. In a phase I clinical trial, it was found to be well-tolerated and showed promising results in terms of its anti-tumor activity. Subsequent phase II and III trials have also shown significant improvements in progression-free survival and overall response rates when Elotuzumab Biosimilar was used in combination with other standard multiple myeloma therapies.

Current and Potential Applications

Currently, Elotuzumab Biosimilar is being investigated as a potential treatment for relapsed or refractory multiple myeloma, either as a monotherapy or in combination with other therapies. It has also shown promise in the treatment of newly diagnosed multiple myeloma, particularly in combination with lenalidomide and dexamethasone.

In addition to multiple myeloma, Elotuzumab Biosimilar is also being studied for its potential use in other types of cancers, such as Waldenstrom macroglobulinemia and non-Hodgkin’s lymphoma, where SLAMF7 is also overexpressed.

Conclusion

In summary, Elotuzumab Biosimilar is a promising therapeutic antibody that specifically targets SLAMF7, a protein that is overexpressed in multiple myeloma cells. Its mechanism of action involves activating the body’s immune system to target and destroy cancer cells. With ongoing research and clinical trials, it has the potential to become a valuable treatment option for multiple myeloma and other cancers.

SDS-PAGE for Elotuzumab Biosimilar - Anti-SLAMF7, CD319 mAb

Elotuzumab Biosimilar - Anti-SLAMF7, CD319 mAb, on SDS-PAGE under reducing and non-reducing condition. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.