Recombinant Human POLDIP2 Protein, N-His

Introduction to Recombinant Human POLDIP2 Protein

Recombinant Human POLDIP2 Protein, also known as Polymerase Delta Interacting Protein 2, is a key protein involved in DNA replication and repair processes. It is a 35 kDa protein that is encoded by the POLDIP2 gene located on chromosome 7 in humans. This protein is highly conserved across species and has been found to play a crucial role in maintaining genomic stability and preventing DNA damage.

Structure of Recombinant Human POLDIP2 Protein

Recombinant Human POLDIP2 Protein is composed of 328 amino acids and has a molecular weight of 35 kDa. It contains several conserved domains, including a Nuclear Localization Signal (NLS) and a C-terminal domain that interacts with the catalytic subunit of DNA polymerase delta. The protein also has a highly conserved central region that is essential for its interaction with other proteins involved in DNA replication and repair.

Activity of Recombinant Human POLDIP2 Protein

Recombinant Human POLDIP2 Protein plays a crucial role in DNA replication and repair processes by interacting with multiple proteins involved in these pathways. It has been shown to interact with the catalytic subunit of DNA polymerase delta, which is responsible for synthesizing new DNA strands during replication. This interaction is essential for the proper functioning of DNA polymerase delta and ensures the accuracy of DNA replication.

Moreover, Recombinant Human POLDIP2 Protein has been found to interact with other important proteins involved in DNA repair, such as proliferating cell nuclear antigen (PCNA) and the DNA repair protein RAD51. These interactions suggest that this protein is involved in maintaining genomic stability and preventing DNA damage.

Application of Recombinant Human POLDIP2 Protein

Recombinant Human POLDIP2 Protein has a wide range of applications in both basic research and clinical settings. Its crucial role in DNA replication and repair processes makes it a valuable tool for studying these pathways and understanding the mechanisms of DNA damage and repair. Additionally, this protein has been found to be dysregulated in various types of cancer, making it a potential target for cancer therapy.

Recombinant Human POLDIP2 Protein has also been used in diagnostic assays to detect DNA damage and monitor the efficacy of DNA repair processes. Its ability to interact with other important proteins involved in DNA repair makes it a valuable marker for assessing the functionality of these pathways.

Furthermore, Recombinant Human POLDIP2 Protein has been investigated as a potential therapeutic target for neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Studies have shown that this protein is involved in maintaining mitochondrial function, and its dysregulation has been linked to these neurodegenerative disorders. Therefore, targeting Recombinant Human POLDIP2 Protein may have therapeutic potential for these diseases.

Conclusion

In summary, Recombinant Human POLDIP2 Protein is a crucial protein involved in DNA replication and repair processes. Its structure, activity, and interactions with other proteins make it a valuable tool for studying these pathways and understanding the mechanisms of DNA damage and repair. Additionally, this protein has potential applications in cancer therapy, diagnostic assays, and as a therapeutic target for neurodegenerative diseases. Further research on Recombinant Human POLDIP2 Protein may lead to a better understanding of its role in maintaining genomic stability and its potential for clinical use.