Recombinant Human NINJ1 Protein, N-GST & C-His

Description of Recombinant Human NINJ1 Protein, N-GST & C-His

Introduction

Recombinant proteins have become an essential tool in various fields of research and medicine. These proteins are produced by genetic engineering techniques, where the gene encoding the protein of interest is inserted into an expression vector and then expressed in a suitable host organism. One such recombinant protein is the Recombinant Human NINJ1 Protein, which has gained significant attention in the scientific community due to its unique structure, activity, and potential applications.

Structure of Recombinant Human NINJ1 Protein

The Recombinant Human NINJ1 Protein, also known as Ninjurin-1, is a glycoprotein that belongs to the immunoglobulin superfamily. It is encoded by the NINJ1 gene located on chromosome 12 in humans. The protein consists of 3 immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic domain. The extracellular domain of NINJ1 contains multiple N-linked glycosylation sites, which are essential for its biological activity.

Activity of Recombinant Human NINJ1 Protein

The primary function of NINJ1 is to mediate cell adhesion and migration. It is expressed on the surface of various cell types, including leukocytes, endothelial cells, and neurons. NINJ1 interacts with other proteins, such as L1CAM and β1 integrin, to promote cell-cell and cell-matrix adhesion. It also plays a crucial role in leukocyte recruitment during inflammation and in the formation of neuronal networks during development.

Moreover, Recombinant Human NINJ1 Protein has been shown to have anti-tumor properties. It inhibits the growth and migration of cancer cells by disrupting their interactions with the extracellular matrix. NINJ1 also promotes the activation of immune cells, such as natural killer cells and T cells, leading to the destruction of cancer cells.

Application of Recombinant Human NINJ1 Protein

Due to its diverse biological functions, Recombinant Human NINJ1 Protein has potential applications in various fields, including immunology, neuroscience, and cancer research.

1. Immunology: NINJ1 is involved in the regulation of immune cell adhesion and migration. Therefore, it has been studied as a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. Recombinant NINJ1 protein can be used to modulate the activity of immune cells and potentially reduce inflammation.

2. Neuroscience: NINJ1 is crucial for the formation of neuronal networks during development. It has been shown to promote axon outgrowth and guidance, as well as synapse formation. Recombinant NINJ1 protein can be used to study the mechanisms of neuronal development and potentially aid in the treatment of neurodegenerative diseases.

3. Cancer Research: As mentioned earlier, NINJ1 has anti-tumor properties and can inhibit the growth and migration of cancer cells. Recombinant NINJ1 protein can be used to further investigate its role in cancer and potentially develop novel therapies for cancer treatment.

Conclusion

The Recombinant Human NINJ1 Protein is a versatile and biologically active protein with potential applications in various fields of research and medicine. Its unique structure and activity make it a valuable tool for studying cell adhesion, migration, and immune responses. Further research on NINJ1 and its potential therapeutic applications could lead to groundbreaking discoveries in the future.