Human ST2 ELISA Kit

Description of Human ST2 ELISA Kit

Introduction

The Human ST2 ELISA Kit is a valuable tool for researchers and clinicians studying the role of ST2 in various diseases and conditions. This kit allows for the accurate and sensitive measurement of ST2 levels in human samples, providing valuable insights into its structure, activity, and potential therapeutic applications.

Structure of ST2

ST2, also known as interleukin-1 receptor-like 1 (IL1RL1), is a member of the interleukin-1 receptor family. It is a transmembrane protein that consists of three domains: an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains three immunoglobulin-like domains, while the intracellular domain contains a Toll/IL-1 receptor (TIR) domain.

Activity of ST2

ST2 is primarily known for its role as a receptor for interleukin-33 (IL-33), a cytokine involved in regulating immune responses and inflammation. When IL-33 binds to ST2, it activates downstream signaling pathways, leading to the production of pro-inflammatory cytokines and chemokines. This makes ST2 an important player in the immune response and inflammation.

Aside from its role as an IL-33 receptor, ST2 has also been shown to have other functions. It has been implicated in tissue remodeling processes, such as wound healing and fibrosis. ST2 has also been found to be expressed on the surface of certain immune cells, such as Th2 cells, regulatory T cells, and mast cells, suggesting a potential role in immune regulation.

Application of Human ST2 ELISA Kit

The Human ST2 ELISA Kit is a valuable tool for researchers studying ST2 in various diseases and conditions. It allows for the accurate and sensitive measurement of ST2 levels in human samples, providing insights into its role and potential as a therapeutic target.

Therapeutic Target

ST2 has been identified as a potential therapeutic target in various diseases, particularly those involving inflammation and immune dysregulation. By measuring ST2 levels using the Human ST2 ELISA Kit, researchers can better understand its role in these diseases and potentially develop targeted therapies to modulate its activity.

For example, in asthma and other allergic diseases, ST2 has been found to be upregulated, leading to increased inflammation and airway hyperresponsiveness. By targeting ST2, it may be possible to reduce the severity of these conditions and improve patient outcomes.

Research Use

The Human ST2 ELISA Kit is also widely used in research to study the role of ST2 in various diseases and conditions. By measuring ST2 levels in different samples, researchers can better understand its expression and activity in different contexts.

For example, the Human ST2 ELISA Kit has been used in studies investigating ST2 levels in cardiovascular diseases, such as heart failure and atherosclerosis. It has also been used to measure ST2 levels in cancer, with some studies suggesting a potential role in tumor growth and metastasis.

Conclusion

The Human ST2 ELISA Kit is a valuable tool for researchers and clinicians studying ST2 in various diseases and conditions. It provides insights into the structure and activity of ST2, as well as its potential as a therapeutic target. Its use in research has also contributed to a better understanding of ST2 and its role in different diseases, paving the way for potential new treatments and interventions.