Ana Reis, PhD
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CAR-T cell therapy
CAR-T cell engineering: strategies to overcome remaining limitations
CAR-T cell engineering is an active field of research. Due to the complexity of these biotherapies, a multi-faceted approach must be used to ensure optimal clinical efficacies while minimizing toxicity.
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How to manufacture CAR-T cells
Manufacturing CAR-T cells is a complex process requiring the collection of T cells from autologous or allogeneic sources and subsequent… Read More
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From the first to the fifth generation of CAR-T cells
Prompted by encouraging clinical and preclinical results, the structure of CAR-T cells has evolved rapidly to minimize off-target toxicity and… Read More
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Cleavable linkers for ADCs
Cleavable linkers are a major class of linkers used in ADC development. As their name indicates, they have inbuilt… Read More
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Non-cleavable linkers for ADCs
Different linker chemistry approaches have been developed since the inception of ADCs. Currently, cleavable and non-cleavable linkers are the… Read More
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How to choose the best linker for an ADC? Cleavable vs. non-cleavable
Antibody-drug conjugate linker chemistry has greatly evolved since the development of the first molecules. Linkers can be defined as… Read More
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How to select the right antibody carrier for ADCs?
Monoclonal antibodies are essential precursors of ADCs. Choosing the proper antibody for the conjugate often dictates its therapeutic efficiency. Several… Read More
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How are antibodies conjugated?
Antibody-drug conjugates (ADC) are one of the fastest-growing classes of biopharmaceuticals. The conjugation between the antibody carrier of… Read More
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Antibody-drug conjugates: Antibody design and conjugation
The careful design and engineering of monoclonal antibody carriers should precede any effort in ADC generation. Target selection and… Read More
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The untapped potential of bispecific antibody therapies
Bispecific antibody therapy makes use of bispecific antibodies for a variety of purposes. This large family of versatile biotherapeutics… Read More