Ana Reis, PhD
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Antibody-drug conjugatesNew and promising trends in therapeutic ADC generation
Ana Reis, PhD
With the growth of the global market for therapeutic antibody-drug conjugates (ADCs), researchers are set on developing exciting new technologies. In the next decades, we will likely witness significant…
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What are the most common targets for ADCs?
Currently, dozens of antibody-drug conjugates (ADCs) and immunotoxins have reached the clinic or are under active clinical development. These… Read More
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Therapeutic ADCs: mechanisms of action and advantages
The therapeutic value of antibody-drug conjugates (ADCs) is widely recognized as highly effective and safe for the treatment of… Read More
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Bioanalysis of antibody-drug conjugates (ADCs)
The bioanalysis of antibody-drug conjugates remains challenging. However, in recent years, many methodologies have been developed to tackle the… Read More
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Assessing the pharmacokinetics of antibody-drug conjugates (ADCs)
Pharmacokinetics (PK) and pharmacodynamics (PD) are two interdependent properties of ADCs. Together, they dictate the clinical outcomes of ADC… Read More
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Key biochemical and biophysical properties of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) are complex molecules. Their key properties are heavily influenced by linker chemistry and antibody conjugation methods. For… Read More
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Robust methods for the detailed analysis of drug-to-antibody ratio (DAR) and drug load distribution
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody-drug conjugates (ADCs). Over the years, several… Read More
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Everything you need to know about the generation of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) consist of three main elements: an antibody carrier, a cleavable or non-cleavable linker, and a bioactive… Read More
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Antibody-antibiotic conjugates for therapeutic applications
Antibody-antibiotic conjugates (AACs) are an emerging class of biotherapeutics for the treatment of infectious diseases. With the rise of antibiotic… Read More
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Antibody-enzyme conjugates for therapeutic applications
Antibody-enzyme conjugates represent a small but growing field of study within the vast topic of payloads for antibody-drug conjugate… Read More
