Vibostolimab Biosimilar – Anti-TIGIT, VSIG9, VSTM3 mAb – Research Grade

Description of Vibostolimab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb - Research Grade

The Structure of Vibostolimab Biosimilar – Anti-TIGIT, VSIG9, VSTM3 mAb

Vibostolimab Biosimilar, also known as Anti-TIGIT, VSIG9, VSTM3 mAb, is a monoclonal antibody (mAb) that has been developed as a potential therapeutic agent for various diseases. This biosimilar is a type of antibody that specifically targets and binds to T-cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), VSIG9, and VSTM3 proteins. These proteins are known to play a crucial role in regulating immune responses, making them attractive therapeutic targets for various diseases.

The structure of Vibostolimab Biosimilar is based on the structure of the original antibody, which was first discovered and characterized by scientists. It is a fully humanized IgG1 antibody, meaning that it is derived from human cells and has a similar structure to the antibodies naturally produced in the human body. This makes it less likely to cause an immune response when administered to patients.

The antibody has a Y-shaped structure, with two identical heavy chains and two identical light chains. Each chain is made up of constant and variable regions. The constant regions are responsible for the effector functions of the antibody, while the variable regions are responsible for binding to the specific target proteins.

The Activity of Vibostolimab Biosimilar

Vibostolimab Biosimilar is a potent inhibitor of TIGIT, VSIG9, and VSTM3 proteins. These proteins are expressed on the surface of various immune cells, including T cells, natural killer (NK) cells, and dendritic cells. When TIGIT, VSIG9, and VSTM3 proteins bind to their ligands, they inhibit immune cell activation, leading to suppression of immune responses.

By binding to these proteins, Vibostolimab Biosimilar blocks their interaction with their ligands, thereby preventing the inhibition of immune cell activation. This results in the enhancement of immune responses, making it a potential therapeutic agent for diseases where immune responses are suppressed, such as cancer and autoimmune diseases.

In addition to its inhibitory activity, Vibostolimab Biosimilar also has the ability to induce antibody-dependent cell-mediated cytotoxicity (ADCC). This means that it can trigger immune cells, such as NK cells, to attack and kill target cells, such as cancer cells, that have been marked by the antibody. This dual mechanism of action makes Vibostolimab Biosimilar a promising candidate for cancer immunotherapy.

The Application of Vibostolimab Biosimilar

Vibostolimab Biosimilar is currently being evaluated in clinical trials for the treatment of various diseases, including solid tumors, hematological malignancies, and autoimmune diseases. In preclinical studies, it has shown promising results in inhibiting tumor growth and enhancing immune responses against cancer cells.

In addition to its potential as a cancer therapy, Vibostolimab Biosimilar is also being investigated for its use in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. By enhancing immune responses, it may help to regulate the overactive immune system and reduce inflammation in these diseases.

Furthermore, the biosimilar is being studied for its potential use in combination with other therapies, such as immune checkpoint inhibitors, to further enhance immune responses and improve treatment outcomes.

Conclusion

In summary, Vibostolimab Biosimilar – Anti-TIGIT, VSIG9, VSTM3 mAb – Research Grade is a promising therapeutic agent with a unique structure and dual mechanism of action. Its ability to inhibit TIGIT, VSIG9, and VSTM3 proteins and induce ADCC makes it a potential treatment option for various diseases, including cancer and autoimmune diseases. Further clinical trials will help to determine its safety and efficacy, and if successful, it could become a valuable addition to the arsenal of therapies available for these diseases.

SDS-PAGE for Vibostolimab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb

Vibostolimab Biosimilar - Anti-TIGIT, VSIG9, VSTM3 mAb, on SDS-PAGE under reducing and non-reducing conditions. The gel was stained overnight with Coomassie Blue. The purity of the antibody is greater than 95%.