Recombinant Human PSMD11 Protein, N-His

Introduction

Recombinant Human PSMD11 Protein, also known as 26S proteasome non-ATPase regulatory subunit 11, is a protein that plays a crucial role in the regulation of protein degradation. This protein is encoded by the PSMD11 gene and is a part of the 26S proteasome complex, which is responsible for the degradation of cellular proteins. Recombinant Human PSMD11 Protein is produced through recombinant DNA technology and has been extensively studied for its structure, activity, and various applications in the field of biotechnology and medicine.

Structure of Recombinant Human PSMD11 Protein

Recombinant Human PSMD11 Protein is a 41 kDa protein consisting of 362 amino acids. It is composed of four structural domains: the N-terminal domain, the coiled-coil domain, the central domain, and the C-terminal domain. The N-terminal domain is responsible for binding to the 26S proteasome complex, while the coiled-coil domain is involved in protein-protein interactions. The central domain contains a zinc finger motif, which is essential for the protein’s function. The C-terminal domain is responsible for binding to the regulatory subunit PSMD9. The overall structure of Recombinant Human PSMD11 Protein is highly conserved among various species, indicating its importance in cellular processes.

Activity of Recombinant Human PSMD11 Protein

Recombinant Human PSMD11 Protein is a non-ATPase regulatory subunit of the 26S proteasome complex. It plays a crucial role in the recognition and degradation of ubiquitinated proteins. This protein binds to the 26S proteasome and recruits ubiquitin-conjugated proteins, which are then degraded by the proteasome. Recombinant Human PSMD11 Protein also plays a role in the regulation of cell cycle progression, DNA damage response, and cellular stress response. It has been shown to interact with various proteins, including transcription factors and signaling molecules, to regulate their degradation.

Applications of Recombinant Human PSMD11 Protein

Recombinant Human PSMD11 Protein has a wide range of applications in the field of biotechnology and medicine. Its ability to regulate protein degradation makes it a valuable tool in protein purification and proteomics research. It can be used as an affinity tag to purify recombinant proteins and as a marker to study protein-protein interactions. Recombinant Human PSMD11 Protein has also been studied for its potential role in cancer therapy. It has been shown to play a role in the degradation of oncoproteins, making it a potential target for cancer treatment.

Furthermore, Recombinant Human PSMD11 Protein has been studied for its role in neurodegenerative diseases. It has been shown to play a role in the degradation of misfolded proteins, which are associated with diseases such as Alzheimer’s and Parkinson’s. This protein has also been implicated in viral infections, as it is involved in the degradation of viral proteins. Thus, Recombinant Human PSMD11 Protein has the potential to be used in the development of antiviral therapies.

Conclusion

In summary, Recombinant Human PSMD11 Protein is a crucial component of the 26S proteasome complex, involved in the regulation of protein degradation. Its structure and activity have been extensively studied, and it has been shown to have various applications in biotechnology and medicine. Further research on this protein may lead to the development of novel therapies for diseases such as cancer and neurodegenerative disorders.