Recombinant Human KIF2C Protein, N-His

Reference: YHK66401
Product nameRecombinant Human KIF2C Protein, N-His
Origin speciesHuman
Expression systemEukaryotic expression
Molecular weight42.79 kDa
BufferLyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
FormLiquid
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandAntibodySystem
Host speciesEscherichia coli (E.coli)
Fragment TypeAsn229-Ser589
Aliases /SynonymsMitotic centromere-associated kinesin, Kinesin-like protein 6, KIF2C, Kinesin-like protein KIF2C, KNSL6, MCAK
ReferenceYHK66401
NoteFor research use only.

Description of Recombinant Human KIF2C Protein, N-His

Introduction

Recombinant Human KIF2C Protein is a highly specialized protein that plays a crucial role in cell division and mitosis. It is a member of the kinesin superfamily, a group of motor proteins that are responsible for transporting various cargo within cells. KIF2C is involved in the separation of duplicated chromosomes during cell division, making it an essential protein for proper cell growth and development.

Structure of Recombinant Human KIF2C Protein

The recombinant human KIF2C protein is a single polypeptide chain consisting of 739 amino acids. It has a molecular weight of approximately 84 kDa. The protein is composed of three main domains: the N-terminal motor domain, the central stalk domain, and the C-terminal tail domain. The motor domain is responsible for the protein’s ATPase activity and microtubule-binding ability. The stalk domain is responsible for the dimerization of KIF2C, which is essential for its function. The tail domain is responsible for the interaction with other proteins and regulatory factors.

Activity of Recombinant Human KIF2C Protein

The primary function of KIF2C is to regulate the separation of duplicated chromosomes during cell division. It accomplishes this by binding to microtubules and using the energy from ATP hydrolysis to move along the microtubule tracks. This movement helps to pull the duplicated chromosomes apart, ensuring that each daughter cell receives the correct number of chromosomes. KIF2C also plays a role in the organization and stabilization of microtubules, which are essential for maintaining cell shape and structure.

In addition to its role in cell division, KIF2C has been implicated in other cellular processes, such as cell migration, cell signaling, and intracellular transport. It has also been shown to interact with various proteins involved in cell cycle regulation and DNA repair, further highlighting its importance in maintaining proper cell function.

Application of Recombinant Human KIF2C Protein

Due to its crucial role in cell division and other cellular processes, recombinant human KIF2C protein has significant potential for various applications in the field of biotechnology and medicine. One of the most promising applications is in cancer research and therapy. KIF2C has been found to be overexpressed in many types of cancer, and its inhibition has been shown to suppress tumor growth and metastasis. Recombinant KIF2C protein can be used to study the protein’s function and develop targeted therapies for cancer treatment.

Another potential application of recombinant human KIF2C protein is in the development of diagnostic tools. As KIF2C is involved in cell division, its levels can serve as a biomarker for various diseases and disorders, including cancer and neurodegenerative diseases. Recombinant KIF2C protein can be used to develop diagnostic tests that can detect abnormal levels of the protein in patient samples.

Furthermore, recombinant human KIF2C protein can also be used in drug discovery and development. As KIF2C plays a critical role in various cellular processes, it can serve as a potential drug target for the treatment of various diseases. Recombinant KIF2C protein can be used in high-throughput screening assays to identify compounds that can inhibit or modulate its activity, leading to the development of new therapeutic agents.

Conclusion

In summary, recombinant human KIF2C protein is a highly specialized protein with a crucial role in cell division and other cellular processes. Its structure, activity, and potential applications make it an important protein for scientific research and medical advancements. Further studies on this protein and its functions can lead to a better understanding of its role in various diseases and the development of novel treatments.

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