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Brand: ProteoGenix

Human CD172a-SIRPA recombinant protein

Host species:
Mammalian cells
Origin species:
Homo sapiens (Human)
Uniprot ID:
P78324
Molecular weight:
41.14 kDa

€319.00

+ 319 loyalty points
Met1–Arg370 His
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Human CD172a-SIRPA recombinant protein

Human CD172a-SIRPA recombinant protein

Product name Human CD172a-SIRPA recombinant protein
Uniprot ID P78324
Origin species Homo sapiens (Human)
Expression system Eukaryotic expression
Molecular weight 41.14 kDa
Protein delivered with Tag? C-Terminal His Tag
Purity estimated >85% by SDS-PAGE
Buffer 0.01M PBS, pH 7.4.
Delivery condition Dry Ice
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Mammalian cells
Fragment Type Met1-Arg370
Aliases /Synonyms BIT, Signal-regulatory protein alpha-1, Brain Ig-like molecule with tyrosine-based activation motifs, MFR, SIRP, Sirp-alpha-1, Sirp-alpha-2, PTPNS1, SIRPA, SHP substrate 1, CD172 antigen-like family member A, Sirp-alpha-3, Inhibitory receptor SHPS-1, Signal-regulatory protein alpha-3, CD172a, Tyrosine-protein phosphatase non-receptor type substrate 1, MyD-1 antigen, Bit, SHPS-1, Macrophage fusion receptor, Signal-regulatory protein alpha-2, SHPS1, MYD1, p84
Reference PX-P6120
Note For research use only
Background information Array
Molecular Constructor
Met1–Arg370 His

General information on Human CD172a-SIRPA recombinant protein

Structure

Human CD172a-SIRPA recombinant protein is a type I transmembrane glycoprotein composed of two extracellular Ig-like domains, a transmembrane domain, and a short cytoplasmic tail. It is encoded by the SHPS-1 gene.

Activity

CD172a-SIRPA protein is a member of the immunoglobulin superfamily that is involved in the regulation of cell-cell interactions. It is known to bind to the CD47 receptor on other cells and inhibit their activation, making it an important immune checkpoint protein.

Application

CD172a-SIRPA recombinant protein has potential applications in the development of antibody-drug conjugates (ADCs) for cancer therapy. It can be used to target cancer cells by binding to CD47 receptors on their surface. This binding triggers an immune response that leads to the destruction of the cancer cells.

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