EGFR / ERBB1 / HER1, C-His, recombinant protein

Description of EGFR / ERBB1 / HER1, C-His, recombinant protein

General information on EGFR / ERBB1 / HER1, C-His, recombinant protein

Structure

EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.

Activity

EGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.

Application

EGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.

Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb (cat. No.PX-TA1305) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 0.5282M.

Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb binds to Human EGFR/ERB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb (cat. No.PX-TA1209) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 159.1M.

Tomuzotuximab Biosimilar - Anti-EGFR mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Tomuzotuximab Biosimilar - Anti-EGFR mAb (cat. No.PX-TA1473) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 0.4532M.