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Brand: ProteoGenix

EGFR / ERBB1 / HER1, C-His, recombinant protein

Host species:
Mammalian cells
Origin species:
Homo sapiens (Human)
Molecular weight:
134.29 kDa

€319.00

+ 319 loyalty points
Met1–Ser645 His
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Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay
Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb binds to Human EGFR/ERB1/HER1 in indirect ELISA Assay
Tomuzotuximab Biosimilar - Anti-EGFR mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

EGFR / ERBB1 / HER1, C-His, recombinant protein

Product name EGFR / ERBB1 / HER1, C-His, recombinant protein
Origin species Homo sapiens (Human)
Expression system Eukaryotic expression
Molecular weight 134.29 kDa
Protein delivered with Tag? C-terminal His Tag
Purity estimated >90% as determined by SDS-PAGE
Buffer PBS, pH7.5
Delivery condition Dry Ice
Delivery lead time in business days 3-5 days if in stock; 3-5 weeks if production needed
Storage condition 4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand ProteoGenix
Host species Mammalian cells
Fragment Type Met1-Ser645
Protein Accession P00533
Reference PX-P5701
Note For research use only.
Molecular Constructor
Met1–Ser645 His

General information on EGFR / ERBB1 / HER1, C-His, recombinant protein

Structure

EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.

Activity

EGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.

Application

EGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.

Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Modotuximab Biosimilar - Anti-EGFR, ERBB1 domain III mAb (cat. No.PX-TA1305) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 0.5282M.

Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb binds to Human EGFR/ERB1/HER1 in indirect ELISA Assay

Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb binds to Human EGFR/ERB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Necitumumab Biosimilar - Anti-EGFR, ERBB1 mAb (cat. No.PX-TA1209) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 159.1M.

Tomuzotuximab Biosimilar - Anti-EGFR mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Tomuzotuximab Biosimilar - Anti-EGFR mAb binds to Human EGFR/ERBB1/HER1 in indirect ELISA Assay

Immobilized EGFR / ERBB1 / HER1, C-His, recombinant protein (cat. No.PX-P5701) at 0.5µg/mL (100µL/well) can bind Tomuzotuximab Biosimilar - Anti-EGFR mAb (cat. No.PX-TA1473) in indirect ELISA with Goat Anti-Human IgG secondary antibody coupled with HRP measured by OD450 giving an EC50 at 0.4532M.

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