3-5 days if in stock; 3-5 weeks if production needed
Storage condition
4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Brand
ProteoGenix
Host species
Mammalian cells
Fragment Type
Met1-Ser645
Protein Accession
P00533
Reference
PX-P5701
Note
For research use only.
Description of EGFR / ERBB1 / HER1, C-His, recombinant protein
General information on EGFR / ERBB1 / HER1, C-His, recombinant protein
Structure
EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.
Activity
EGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.
Application
EGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.
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