Brand: ProteoGenix

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

ARO-A23060-100
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Clonality:: Monoclonal Antibody

Original price was: €399.00.Current price is: €330.00.

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50ug Original price was: €314.00.Current price is: €231.00.
100ug Original price was: €399.00.Current price is: €330.00.
1MG Original price was: €1,196.00.Current price is: €957.00.

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Datasheet

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Product name	ARO-A23060-100
Delivery condition	Blue ice (+4°C)
Delivery lead time in business days	3-5 days if in stock; 3-5 weeks if production needed
Storage condition	4°C for short term (1 week), store at -20°C to -80°C for long term(1 year); Avoid repeated freeze-thaw cycles
Brand	ProteoGenix
Aliases /Synonyms	Anti-RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.
Clonality	Monoclonal Antibody
Protein Name	RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.

Product name	ARO-A23060-1MG
Delivery condition	Blue ice (+4°C)
Delivery lead time in business days	3-5 days if in stock; 3-5 weeks if production needed
Storage condition	4°C for short term (1 week), store at -20°C to -80°C for long term(1 year); Avoid repeated freeze-thaw cycles
Brand	ProteoGenix
Aliases /Synonyms	Anti-RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.
Clonality	Monoclonal Antibody
Protein Name	RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.

Product name	ARO-A23060-50
Delivery condition	Blue ice (+4°C)
Delivery lead time in business days	3-5 days if in stock; 3-5 weeks if production needed
Storage condition	4°C for short term (1 week), store at -20°C to -80°C for long term(1 year); Avoid repeated freeze-thaw cycles
Brand	ProteoGenix
Aliases /Synonyms	Anti-RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.
Clonality	Monoclonal Antibody
Protein Name	RecName: Full=Envelope glycoprotein; AltName: Full=GP1,2; Short=GP; Contains: RecName: Full=Shed GP; AltName: Full=GP1,2-delta; Contains: RecName: Full=GP1; Contains: RecName: Full=GP2; Flags: Precursor, GP, GP1,2, /evidence=ECO:0000255., Filovirus glycoprotein; pfam01611, Envelope glycoprotein. /id=PRO_0000037485., Extracellular. /evidence=ECO:0000255., Shed GP. /id=PRO_0000445686., GP1. /id=PRO_0000037486., /evidence=ECO:0007829\|PDB:6HS4., N->D: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Interchain (between GP1 and GP2 chains). /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6QD7., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., Receptor-binding. /evidence=ECO:0000255., D->A: 80% loss of virus capability to enter into host cell., D->E,K: No effect on viral entry., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: Complete loss of virus capability to enter into host cell., L->F,I,K: 90% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., L->A: 90% loss of virus capability to enter into host cell., L->F: Almost complete loss of virus capability to enter into host cell., L->K: Complete loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., R->A,E: Complete loss of virus capability to enter into host cell., R->K: No loss of virus capability to enter into host cell., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., F->A,E: Complete loss of virus capability to enter into host cell., F->A: About 50% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., F->I: No loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., K->A,E: 80% loss of virus capability to enter into host cell., K->R: 20% loss of virus capability to enter into host cell., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Almost complete loss of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:9BSV., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->G: Reduced levels of expression of GP1 and GP2. 50% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., L->A: About 60% loss of ability to counteract host BST2. /evidence=ECO:0000269\|PubMed:27707924., /evidence=ECO:0007829\|PDB:6HS4., C->S: Almost complete loss of expression of GP1 and GP2. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->S: Reduced levels of expression of GP1 and GP2. Almost complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I->A: 90% loss of virus capability to enter into host cell., I->E: Complete loss of virus capability to enter into host cell., I->F: 50% loss of virus capability to enter into host cell., Involved in receptor recognition and/or post-binding events. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7JPI., /evidence=ECO:0007829\|PDB:7JPI., N->D: No effect on GP1 and GP2 expression. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., N->Y: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., S -> P (in strain: Isolate mouse-adapted)., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 12% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., N->D: No effect on GP1 and GP2 expression. 18% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:7TN9., Mucin-like region., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:7LYD., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., invasion associated endopeptidase, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., RRTRR->AGTAA: Almost complete loss of cleavage between GP1 and GP2. No loss of infectivity. /evidence=ECO:0000269\|PubMed:11152533., RTRR->ATAA: No effect on cleavage between GP1 and GP2. /evidence=ECO:0000269\|PubMed:9882347., Cleavage; by host furin. /evidence=ECO:0000269\|PubMed:9576958., GP2. /id=PRO_0000037487., /evidence=ECO:0000255., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:8DPM., Fusion peptide. /evidence=ECO:0000305., /evidence=ECO:0007829\|PDB:6HS4., G->R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., L->A,R: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., I->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., F->A: Reduced infectivity. /evidence=ECO:0000269\|PubMed:10482652., F->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., G->A: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., P->R: Almost complete loss of infectivity. No effect on transport of GP to the cell surface and incorporation onto virions. /evidence=ECO:0000269\|PubMed:10482652., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0007829\|PDB:6HS4., I -> T., /evidence=ECO:0007829\|PDB:6HS4., /evidence=ECO:0000255., C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, /evidence=ECO:0007829\|PDB:2EBO., N->D: Reduced levels of expression of GP, GP1 and GP2. 20% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0007829\|PDB:2EBO., /evidence=ECO:0000269\|PubMed:12438572., CX(6,7)C motif, C->S: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0007829\|PDB:2EBO., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., C->G: Induces GP1 secretion. Complete loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:2EBO., HR2, N->D: Slightly reduced levels of expression of GP1 and GP2. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:12438572., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., K->R,V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., T->I: 50% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: 60% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., L->V: Increased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., P->A: 60% loss of release of soluble GP1,2delta., Cleavage; by host ADAM17. /evidence=ECO:0000269\|PubMed:15103332., D->E: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->L,V: Increased release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: Decreased GP shedding. /evidence=ECO:0000269\|PubMed:26092855., Q->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., G->V: 40% loss of release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., D->V: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., N->A: No effect on release of soluble GP1,2delta. /evidence=ECO:0000269\|PubMed:15103332., Helical. /evidence=ECO:0000255., Important role for host BST2/tetherin antagonism. /evidence=ECO:0000269\|PubMed:27707924., G->L: About 60% loss of viral release; when associated with L-664. /evidence=ECO:0000269\|PubMed:29669839., A->L: About 60% loss of viral release; when associated with L-660. /evidence=ECO:0000269\|PubMed:29669839., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-670. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Greatly reduced GP processing and association with retrovirus particle. 43% loss of virus capability to enter into host cell. Loss of localization to the rafts; when associated with A-672. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:11877482, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Cytoplasmic. /evidence=ECO:0000255., C->A: Reduced palmitoylation. No effect on GP processing and association with retrovirus particle. No loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., C->F: Slightly reduced levels of expression of GP1 and GP2. Almost no effect on GP processing and association with retrovirus particle. 24% loss of virus capability to enter into host cell. /evidence=ECO:0000269\|PubMed:11152533, ECO:0000269\|PubMed:12438572., S-palmitoyl cysteine; by host. /evidence=ECO:0000269\|PubMed:11152533., Nucleocapsid protein; Protein N, Nucleoprotein. /id=PRO_0000222174., Ebola nucleoprotein; pfam05505, /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Acidic residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U55., /evidence=ECO:0007829\|PDB:6U52., /evidence=ECO:0007829\|PDB:6U52., GP1,2; Virion spike glycoprotein, Filovirus glycoprotein; pfam01611, /evidence=ECO:0000250., Envelope glycoprotein. /evidence=ECO:0000250. /id=PRO_0000314986., Extracellular. /evidence=ECO:0000255., GP1. /evidence=ECO:0000250. /id=PRO_0000314987., Receptor-binding. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., Mucin-like region. /evidence=ECO:0000250., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Polar residues. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Low complexity. /evidence=ECO:0000256\|SAM:MobiDB-lite., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Cleavage; by host furin. /evidence=ECO:0000250., GP2. /evidence=ECO:0000250. /id=PRO_0000314988., /evidence=ECO:0007829\|PDB:6BP2., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., Fusion peptide. /evidence=ECO:0000250., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., /evidence=ECO:0007829\|PDB:6BP2., heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains; cd09850, homotrimer interface [polypeptide binding], HR1-GP1 interface [polypeptide binding], HR1A, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., HR1B, HR1C, HR1D, Cl binding site [ion binding], immunosuppressive region, /evidence=ECO:0007829\|PDB:6BP2., CX(6,7)C motif, /evidence=ECO:0007829\|PDB:6BP2., HR2, N-linked (GlcNAc...) asparagine; by host. /evidence=ECO:0000255., Helical. /evidence=ECO:0000255., Cytoplasmic. /evidence=ECO:0000255., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253., S-palmitoyl cysteine; by host. /evidence=ECO:0000250\|UniProtKB:P35253.

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Introducing Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10), a highly specialized and effective tool for the detection and treatment of various filoviruses. This powerful antibody targets the glycoprotein (GP) and envelope (Env) of multiple filoviruses, making it a valuable asset in the field of biotechnology.

Biological Function

The Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10) works by binding to the GP and Env proteins found on the surface of filoviruses. These proteins are essential for the virus to enter and infect host cells. By targeting these proteins, the antibody effectively neutralizes the virus and prevents its replication, ultimately leading to its elimination from the body.

Main Applications

This antibody has a wide range of applications in the biotech industry. It is primarily used for the detection and diagnosis of filovirus infections, including Ebola and Marburg viruses. It is also a valuable tool for research and development in the field of virology, as it allows for the identification and characterization of different filovirus strains.

Experimental Use Cases

The Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10) has been extensively tested and proven to be highly effective in various experimental settings. In one study, it was used to successfully detect and neutralize multiple filovirus strains in infected cells. In another study, it was utilized to develop a rapid diagnostic test for filovirus infections, providing accurate results in a matter of minutes.

Keywords

Filovirus, GP, Env, antibody, detection, treatment, biotechnology, neutralizes, replication, elimination, diagnosis, Ebola, Marburg, virology, strains, infected cells, rapid diagnostic test, accurate results.

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Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Biological Function

Main Applications

Experimental Use Cases

Keywords

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Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Specifications Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Description

Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)

Biological Function

Main Applications

Experimental Use Cases

Keywords

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Anti-pan-Filovirus GP/Envelope glycoprotein Antibody (m21D10)