General information on Anti-CoV-RBD (E4) antibody
The anti-CoV-RBD (E4) antibody is an anti-SARS-CoV-2 with potential neutralizing activity identified by screening a vast COVID-19 antibody library (LiAb-SFCOVID-19™) against the receptor-binding domain (RBD) of the new coronavirus. Produced in IgG format, the variant was shown to be stable and to consistently yield high and consistent amounts when expressed in XtenCHO™, a transient mammalian expression system based on an engineered CHO cell line.
The specificity and affinity of this IgG antibody have been tested in ELISA (enzyme-linked immunosorbent assay) plates against the purified and recombinant form of the RBD. Additionally, the neutralizing capacity was confirmed indirectly using the SARS-CoV-2 Surrogate Virus Neutralization Test (sVNT) assay, which was designed for the quick and accurate screening of antibody variants for their ability to block the interaction between RBD and its specific human receptor ACE2.
Since the beginning of the pandemic, numerous studies confirmed the therapeutic potential of SARS-CoV-2 NAbs (neutralizing antibodies). The reason for the preference of RBD over other domains of SARS-CoV-2 stems from its key role in the initiation of the viral infection. By blocking this important interaction, researchers expect to arrest the progression of the disease.
Antibody therapeutics also presents a unique advantage over small molecules for the treatment of COVID-19. Most antiviral drugs are, in fact, known to suppress the immune response, which often delays the elimination of viral particles from the patient’s organism. On the contrary, antibody therapeutics further engage and activate the immune system of individuals, leading to a synergic action between the an antibody’s blocking activity and faster and safer viral clearance of pathogens.
In this context, research neutralizing antibodies such as anti-CoV-RBD (E4) serve to investigate the progression of the disease and the organism’s response to specific therapies.
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