Zika ZGE Recombinant Protein-Genome polyprotein

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Product nameZika ZGE Recombinant Protein-Genome polyprotein
Uniprot IDA0A140E7U5
Uniprot linkhttp://www.uniprot.org/uniprot/A0A140E7U5
Origin speciesZika
Expression systemProcaryotic expression
SequenceMIRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTAMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMLVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLAHKEWFHDIPLPWHAGAATGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETVDGTVTVEGQYGGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGALNSLGKGIHQIIGAAFKLEHHHHHH
Molecular weight54.6 kDa
Purity estimated85%
BufferPBS,pH7.5
FormFrozen
Delivery conditionDry Ice
Delivery lead time in business days10-25
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
Fragment TypePartial
Aliases /SynonymsZGE, Genome polyprotein
ReferencePX-P3065
Publications1. "Complete Genome Sequence of Zika Virus from the First Imported Case in Mainland China." Liu L., Wu W., Zhao X., Xiong Y., Zhang S., Liu X., Qu J., Li J., Nei K., Liang M., Shu Y., Hu G., Ma X., Li D. Genome Announc. 4:e00291-16(2016) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Category: Sequences. Strain: VE_GanxianImported. Source: UniProtKB/TrEMBL (unreviewed).
NoteFor research use only

General information on Zika ZGE Recombinant Protein/Genome polyprotein

The genome of Zika virus encodes a single polyprotein that is co- and post-translationally cleaved to generate 13 proteins. For example the peptide pr prevents premature fusion activity of envelope proteins in trans Golgi by binding to envelope protein E at pH6.0. After virion release in extracellular space gets dissociated from E dimers. Non-structural protein 4A induces host endoplasmic regulate the ATPase activity of the NS3 helicase. Non-structural protein 1 is implicated in immune evasion, pathogenesis and viral replication. Once cleaved off the polyprotein is targeted to three destinations: the viral replication cycle, the plasma membrane and the extracellular compartment. It may play a role in viral genome replication etc.

Publication

1. "Complete Genome Sequence of Zika Virus from the First Imported Case in Mainland China." Liu L., Wu W., Zhao X., Xiong Y., Zhang S., Liu X., Qu J., Li J., Nei K., Liang M., Shu Y., Hu G., Ma X., Li D. Genome Announc. 4:e00291-16(2016) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Category: Sequences. Strain: VE_GanxianImported. Source: UniProtKB/TrEMBL (unreviewed).

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