Recombinant Mouse IL4 Protein, N-His-SUMO

Description of Recombinant Mouse IL4 Protein, N-His-SUMO

Introduction

Recombinant Mouse IL4 Protein, also known as Interleukin 4, is a cytokine that plays a crucial role in immune response and inflammation. It is a member of the interleukin family, which are signaling molecules that regulate various cellular processes in the immune system. Recombinant Mouse IL4 Protein is produced through genetic engineering techniques, making it a highly pure and potent form of the protein. In this article, we will discuss the structure, activity, and application of Recombinant Mouse IL4 Protein.

Structure of Recombinant Mouse IL4 Protein

Recombinant Mouse IL4 Protein is a small, globular protein with a molecular weight of approximately 15 kDa. It is composed of 129 amino acids and contains two alpha helices and four beta strands. The protein has a conserved disulfide bond between cysteine residues at positions 6 and 127, which is essential for its stability and biological activity. The structure of Recombinant Mouse IL4 Protein is similar to that of human IL4, with a high degree of sequence homology.

Activity of Recombinant Mouse IL4 Protein

Recombinant Mouse IL4 Protein is a potent immunomodulatory cytokine that exerts its effects by binding to its receptor, IL4Rα, which is expressed on various immune cells such as T cells, B cells, and macrophages. Upon binding, Recombinant Mouse IL4 Protein triggers a signaling cascade that leads to the activation of downstream pathways, including the JAK/STAT and PI3K/AKT pathways. This results in the production of anti-inflammatory cytokines, such as IL10, and the inhibition of pro-inflammatory cytokines, such as IL1 and TNF-α.

One of the key functions of Recombinant Mouse IL4 Protein is its ability to promote the differentiation of naive T cells into Th2 cells, which are crucial for the humoral immune response. Th2 cells produce IL4, IL5, and IL13, which are involved in the recruitment and activation of immune cells, such as eosinophils and basophils, in response to parasitic infections and allergies. Additionally, Recombinant Mouse IL4 Protein also plays a role in the differentiation of B cells into antibody-producing plasma cells, further enhancing the humoral immune response.

Applications of Recombinant Mouse IL4 Protein

Recombinant Mouse IL4 Protein has various applications in both basic research and clinical settings. In basic research, it is commonly used as a tool to study the role of IL4 in immune response and inflammation. It can be used to stimulate immune cells in vitro and observe their response, or to induce inflammation in animal models. Recombinant Mouse IL4 Protein is also used in the development of IL4-specific antibodies and other biological reagents.

In clinical settings, Recombinant Mouse IL4 Protein has been investigated as a potential therapeutic agent for various diseases, including inflammatory disorders, autoimmune diseases, and cancer. Its ability to modulate the immune response and promote anti-inflammatory cytokine production makes it a promising candidate for the treatment of conditions such as asthma, atopic dermatitis, and rheumatoid arthritis. Additionally, studies have shown that Recombinant Mouse IL4 Protein can inhibit the growth of certain types of cancer cells, making it a potential adjuvant therapy for cancer treatment.

Conclusion

Recombinant Mouse IL4 Protein is a potent cytokine with diverse functions in the immune system. Its unique structure and activity make it a valuable tool for both basic research and clinical applications. With ongoing research, the potential of Recombinant Mouse IL4 Protein as a therapeutic agent continues to expand, offering new possibilities for the treatment of various diseases.