Recombinant Human P2RX4 Protein, N-His

Description of Recombinant Human P2RX4 Protein, N-His

Introduction

The Recombinant Human P2RX4 Protein is a type of recombinant protein that plays a crucial role in various biological processes. This protein is a member of the purinergic receptor family, specifically the P2X receptor subfamily. It is encoded by the P2RX4 gene and is found in various tissues and cells in the human body.

Structure of Recombinant Human P2RX4 Protein

The Recombinant Human P2RX4 Protein is a transmembrane protein that consists of 397 amino acids. It has two transmembrane domains, a large extracellular loop, and intracellular N and C termini. The extracellular loop contains the binding site for ATP, the ligand that activates the receptor. The intracellular domains are responsible for signal transduction and interaction with other proteins.

The protein also has two glycosylation sites, which play a role in its stability and function. The molecular weight of the protein is approximately 44 kDa.

Activity of Recombinant Human P2RX4 Protein

The Recombinant Human P2RX4 Protein is a ligand-gated ion channel, meaning it opens in response to the binding of a specific ligand. In this case, the ligand is ATP. When ATP binds to the receptor, it causes a conformational change that allows ions, such as calcium and sodium, to flow into the cell. This influx of ions leads to various physiological responses, including neurotransmission, immune response, and cell proliferation.

The activity of this protein is also regulated by other factors, such as pH and extracellular calcium levels. It has been shown to play a role in pain perception, inflammation, and cell death.

Application of Recombinant Human P2RX4 Protein

The Recombinant Human P2RX4 Protein has various applications in both research and therapeutic settings. It is commonly used as an antigen in studies investigating the function and regulation of purinergic receptors. It can also be used to screen for potential drugs that target this receptor and modulate its activity.

In therapeutic applications, this protein has shown potential in treating various diseases and conditions. For example, it has been studied as a potential target for pain management, as it plays a role in pain perception. It has also been investigated for its role in inflammation and immune response, making it a potential target for treating inflammatory diseases and disorders.

Furthermore, the Recombinant Human P2RX4 Protein has been studied in the context of cancer. It has been found to be overexpressed in certain types of cancer, and targeting this protein may be a potential strategy for cancer treatment.

Conclusion

The Recombinant Human P2RX4 Protein is a crucial player in various biological processes and has numerous applications in research and therapeutics. Its unique structure and activity make it an important target for drug development and further understanding of its role in various diseases. As research on this protein continues, it may lead to new treatments and therapies for a range of conditions.