Recombinant Human LMOD3 Protein, N-His

Description of Recombinant Human LMOD3 Protein, N-His

Introduction

Recombinant Human LMOD3 Protein, also known as Leiomodin-3, is a protein that plays a crucial role in regulating actin dynamics in muscle cells. It is a member of the LMOD family of proteins and is encoded by the LMOD3 gene. In this article, we will explore the structure, activity, and applications of this important recombinant protein.

Structure of Recombinant Human LMOD3 Protein

Recombinant Human LMOD3 Protein is a 60 kDa protein that consists of 547 amino acids. It has a highly conserved N-terminal domain and a C-terminal domain that is specific to LMOD3. The N-terminal domain contains a series of tandem repeats that are responsible for binding to actin filaments. The C-terminal domain, on the other hand, contains a leucine-rich repeat motif that is involved in protein-protein interactions.

Activity of Recombinant Human LMOD3 Protein

Recombinant Human LMOD3 Protein is primarily involved in the regulation of actin dynamics in muscle cells. It binds to actin filaments and promotes their elongation, leading to the formation of new actin filaments. This activity is crucial for the proper functioning of muscle cells, as actin filaments are essential for muscle contraction.

In addition to its role in actin dynamics, Recombinant Human LMOD3 Protein has also been shown to interact with other proteins involved in muscle function, such as tropomyosin and myosin. These interactions further contribute to its role in regulating muscle contraction.

Applications of Recombinant Human LMOD3 Protein

Recombinant Human LMOD3 Protein has a wide range of applications in both research and clinical settings. Its ability to regulate actin dynamics makes it a valuable tool for studying the molecular mechanisms underlying muscle function. It has been used in various studies to investigate the role of actin filaments in muscle contraction and to understand the pathophysiology of muscle disorders.

Moreover, Recombinant Human LMOD3 Protein has potential therapeutic applications. Mutations in the LMOD3 gene have been linked to several muscle disorders, such as nemaline myopathy and congenital myopathy. Recombinant Human LMOD3 Protein can be used to study these mutations and develop potential treatments for these disorders.

Furthermore, Recombinant Human LMOD3 Protein has also been used in the development of diagnostic tools for muscle disorders. Its ability to interact with other muscle proteins, such as tropomyosin and myosin, makes it a potential antigen for the detection of antibodies in patients with muscle disorders.

Conclusion

Recombinant Human LMOD3 Protein is a crucial protein involved in the regulation of actin dynamics in muscle cells. Its structure, activity, and applications make it a valuable tool for studying the molecular mechanisms underlying muscle function and for developing potential treatments and diagnostic tools for muscle disorders. Further research on this protein is needed to fully understand its role in muscle function and to explore its potential therapeutic applications.