Recombinant Human CARM1 Protein, N-His

Reference: YHK50101
Product nameRecombinant Human CARM1 Protein, N-His
Origin speciesHuman
Expression systemEukaryotic expression
Molecular weight52.22 kDa
BufferLyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Delivery conditionDry Ice
Delivery lead time in business days3-5 days if in stock; 3-5 weeks if production needed
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
Host speciesEscherichia coli (E.coli)
Fragment TypeThr28-Asn471
Aliases /SynonymsHistone-arginine methyltransferase CARM1, CARM1, Coactivator-associated arginine methyltransferase 1, PRMT4, Protein arginine N-methyltransferase 4
NoteFor research use only.

Description of Recombinant Human CARM1 Protein, N-His


Recombinant Human CARM1 Protein is a highly purified and biologically active protein that is produced through recombinant DNA technology. This protein plays a crucial role in various cellular processes and has been extensively studied for its structure, activity, and potential applications in research and medicine.

Structure of Recombinant Human CARM1 Protein

The Recombinant Human CARM1 Protein is a 68 kDa protein consisting of 608 amino acids. It is a member of the arginine methyltransferase family and contains a catalytic domain and a C-terminal domain. The catalytic domain is responsible for the enzymatic activity of CARM1, while the C-terminal domain is involved in protein-protein interactions. The protein also contains a nuclear localization signal, indicating its role in the nucleus.

Activity of Recombinant Human CARM1 Protein

Recombinant Human CARM1 Protein is a type I protein arginine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the guanidino nitrogen of arginine residues in target proteins. This post-translational modification, known as arginine methylation, plays a crucial role in regulating protein function and cellular processes such as transcription, RNA processing, and DNA damage response. CARM1 is known to methylate a variety of target proteins, including histones, transcription factors, and RNA-binding proteins.

Studies have shown that CARM1 is involved in the regulation of gene expression by modulating the activity of transcription factors, such as p53 and NF-κB. It also plays a role in alternative splicing of pre-mRNA, which is essential for the production of different protein isoforms. Additionally, CARM1 has been implicated in DNA damage response, as it is recruited to sites of DNA damage and promotes DNA repair through its interaction with key repair proteins.

Application of Recombinant Human CARM1 Protein

The unique structure and activity of Recombinant Human CARM1 Protein make it a valuable tool for various research applications. One of the major applications of this protein is in the study of epigenetics and chromatin biology. CARM1 has been shown to play a critical role in the epigenetic regulation of gene expression through its ability to methylate histones and other chromatin-associated proteins. Its role in transcriptional regulation also makes it a useful tool for studying gene expression and its dysregulation in diseases such as cancer.

Another potential application of Recombinant Human CARM1 Protein is in drug discovery and development. As CARM1 has been linked to various cellular processes and diseases, it is a potential target for therapeutic interventions. Recombinant Human CARM1 Protein can be used to screen for small molecule inhibitors or activators of CARM1, which could have therapeutic potential in diseases associated with dysregulated CARM1 activity.

In addition, Recombinant Human CARM1 Protein can also be used as an antigen for the development of antibodies and diagnostic assays. As CARM1 is overexpressed in certain cancers, it can serve as a biomarker for cancer diagnosis and prognosis. The availability of highly pure and active Recombinant Human CARM1 Protein makes it an ideal antigen for the production of specific antibodies for use in diagnostic tests.


Recombinant Human CARM1 Protein is a crucial protein with diverse roles in cellular processes. Its unique structure and activity make it a valuable tool for various research applications, including epigenetics, drug discovery, and diagnostics. Further studies on the structure and function of CARM1 will provide insights into its role in health and disease, and may lead to the development of novel therapeutic strategies.


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