Recombinant Human C reactive protein (CRP)

Reference:
Product nameRecombinant Human C reactive protein (CRP)
Uniprot IDP02741
Uniprot linkhttp://www.uniprot.org/uniprot/P02741
Origin speciesHomo sapiens (Human)
Expression systemProkaryotic expression
Molecular weight22.66kDa
Protein delivered with Tag?C-terminal His Tag
Purity estimated90%
BufferPBS, pH7.5
Delivery conditionDry Ice
Delivery lead time in business daysEurope: 5-7 working days
USA & Canada: 7-10 working days
Rest of the world: 5-12 working days
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesEscherichia coli (E.coli)
ApplicationsELISA,WB
Fragment TypeGln19-Pro224
Protein AccessionP02741
Aliases /SynonymsCRP, C-RP, PTX1, Pentraxin-Related, Pentraxin 1
ReferencePX-P4056
NoteFor research use only

Description of Recombinant Human C reactive protein (CRP)

General Information about Recombinant Human C reactive protein (CRP)

C-reactive protein (CRP) is a member of the pentacycline family of proteins, which is characterized by a cyclic pentameric structure. The pioneer of the human CRP gene that codes for 224 amino acids. The mature human CRP protein has 206 unbound amino acids, which can form a pentapeptide table. The homologous sequence homology between human CRP and mouse and rat is 71% and 64%, respectively. CRP synthesized by liver cells is the major acute serum protein in humans. IL6, IL1 and glucocorticoids are the main inducers of CRP genes. The physiological role of CRP is to bind to phosphorylcholine expressed on the surface of dead or dying cells (and some types of bacteria) to activate the complement system. CRP binds to phosphocholine and destructive cells on microorganisms and improves phagocytosis of macrophages. Therefore, CRP is involved in the consumption of necrotic and apoptotic cells. In acute inflammation (such as infection), CRP can increase by 50,000 times. It will exceed the normal limit within 6 hours and peak in 48 hours. Its duration is constant, so its level mainly depends on productivity. High CRP levels in the human body have been shown to be associated with an increased risk of cardiovascular disease.

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